Vasoplegia Syndrome Clinical Trial
Official title:
Dynamic Arterial Elastance Measured by Uncalibrated Pulse Contour Analysis Predicts Arterial Pressure Response to a Decrease in Norepinephrine (VESA) Dynamic Arterial Elastance Measured by Uncalibrated Pulse Contour Analysis
Dynamic arterial elastance (Eadyn) has been proposed as an indicator of arterial tone that can predict norepinephrine-dependent arterial pressure. Eadyn is calculated using the ratio of respiratory pulse pressure variation (PPV) over the respiratory stroke volume variation (SVV). Guinot et al demonstrated a decrease in the duration of norepinephrine treatment with the use of Eadyn. To date, studies that have validated Eadyn at bedside have used cardiac output (CO) calibrated pulse contour analysis (PiCCO™, Pulsion™) or oesophageal doppler. Such monitoring systems need dedicated and specific arterial line and venous access that may limit their use at bedside. In addition to CO calibrated pulse contour analysis, CO uncalibrated pulse contour analysis has been developed and is considered less invasive. Nevertheless, one limitation of the latter CO monitoring is inaccuracy of CO measurement in patients who are being treated with norepinephrine. These limitations may affect the predictability of Eadyn. We conducted a prospective study in a university hospital ICU. Patients with vasoplegic syndrome for whom the intensive care physician planned to decrease the norepinephrine dosage were included. Hemodynamic and uncalibrated pulse contour analysis (Volume view, FloTrac, Edwards Lifescience, Irvine) values were obtained before and after decreasing the norepinephrine dosage. Responders were defined by a >10% decrease in mean arterial pressure (MAP).
- Background : Dynamic arterial elastance (Eadyn) has been proposed as an indicator of
arterial tone that can predict norepinephrine-dependent arterial pressure. Eadyn is
calculated using the ratio of respiratory pulse pressure variation (PPV) over the
respiratory stroke volume variation (SVV). Guinot et al demonstrated a decrease in the
duration of norepinephrine treatment with the use of Eadyn. To date, studies that have
validated Eadyn at bedside have used cardiac output (CO) calibrated pulse contour
analysis (PiCCO™, Pulsion™) or oesophageal doppler. Such monitoring systems need
dedicated and specific arterial line and venous access that may limit their use at
bedside. In addition to CO calibrated pulse contour analysis, CO uncalibrated pulse
contour analysis has been developed and is considered less invasive. Nevertheless, one
limitation of the latter CO monitoring is inaccuracy of CO measurement in patients who
are being treated with norepinephrine. These limitations may affect the predictability
of Eadyn.
- Purpose : To date, no study has evaluated the ability of Eadyn measured by uncalibrated
pulse contour analysis to assess arterial pressure response to a decreased dose of
norepinephrine. We tested the hypothesis that Eadyn calculated from uncalibrated pulse
contour analysis predicts the arterial-pressure response to a norepinephrine decrease in
patients treated with norepinephrine
;