Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation

Vasomotor Rhinitis Clinical Trial

Official title: Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation

Status Completed

Clinical Trial Summary

This study seeks to compare patients with vasomotor rhinitis ("perennial nonallergic rhinitis," "idiopathic rhinitis") with normal controls with respect to their nasal physiologic reactivity to cold air challenge. Ten vasomotor rhinitis (VMR) patients with nasal symptoms triggered predominantly by cold air, four VMR patients with symptoms triggered predominantly by chemicals, and ten nonallergic, non-rhinitic control subjects will be studied.

Clinical Trial Description

After initial screening and verification that subjects can cooperate with active posterior rhinomanometry, subjects will be scheduled for two 15-minute exposure sessions with either: cold-dry air, or warm-moist air. Subjects will rate symptoms (and have their nasal airway resistance measured in triplicate) prior to exposure and at 15-min. intervals post-exposure until an hour has passed. ;

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Diagnostic

Related Conditions & MeSH terms

• Rhinitis
• Rhinitis, Vasomotor
• Vasomotor Rhinitis

• NCT number: NCT00415493
• Study type: Interventional
• Source: Associated Scientists to Help Minimize Allergies
• Status: Completed
• Phase: N/A
• Start date: December 2006
• Completion date: May 2008