Vasoconstriction Clinical Trial
Official title:
Evidence of Spreading Vasoconstriction in Human Gingiva
The aim of this study is to observe the mechanism of spreading vasoconstriction in human healthy gingiva. Epinephrine solution is applied on the attached gingiva in group "A" and on the surface of the tooth next to the ginvial sulcus in group "B". The different placement of the solution causes different effect in the microcirculation.
Spatial regulation of gingival microcirculation has not been revealed yet. Although this
could be an important mechanism to protect gingiva as it is exposed to mechanical, chemical,
thermal etc. irritation during whole life. It is especially important during flap surgery.
Laser Speckle Contrast Imaging (LSCI) is novel non-invasive method with high spatio-temporal
resolution, therefore it allows us to study remote effect of local vasoconstriction such as
spreading vasoconstriction in human gingiva.
The epinephrine is a daily used vasoconstrictor material in dentistry and it will be used to
trigger remote effect on gingiva. Epinephrine in 1 mg/ml concentration. Solution will be
dropped on the gingiva at tooth 12 in a fabricated leakage proof well attached to 2mm above
the marginal gingiva in group "A". The solution will be dropped on the surface of tooth 12
next to the sulcus into the well in case of group "B". The changes of the blood flow will be
monitor at the test side with surrounding gingival area by LSCI. The control side in each
case will be - appropriately to the test side - at tooth 21 with phisiologocal saline.
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