Evaluation of Accelerated Sampling Techniques for Vessel Wall Imaging

Vasculopathy Clinical Trial

Official title:

Optimizing Scan Efficiency of T1-weighted (T1w) Imaging for Vessel Wall Imaging Protocols

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06392347
• Other study ID #: 853628
• Status: Recruiting
• Start date: October 23, 2023
• Est. completion date: July 2028

Study information

• Verified date: May 2024
• Source: University of Pennsylvania
• Contact: Jae Song, MD
• Phone: 215-349-8023
• Email: jae.song[@]pennmedicine.upenn.edu
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to compare and evaluate a faster MR image that has been optimized to look at participants blood vessel walls.

Description:

The purpose of this study is to compare and evaluate a faster MR image that has been optimized to look at participants blood vessel walls. This faster MR image technique will image participants blood vessel walls in a shorter period of time and will be compared to the routine MR images that is typically used to image participants blood vessel walls.

The purpose of testing these faster images is to compare the image quality with longer conventional images. The goal is to ensure the investigators maintain high image quality over a shorter period of time. These faster images over a shorter period of time have the advantage of fewer motion-related artifacts.

The hypothesis of this research study is that the compressed sensing (fast acquisition technique) based acquisitions will considerably reduce the scan time and will maintain the diagnostic image quality necessary for the assessment of participants blood vessel walls. Thus, the information gained from this study will help us to determine the efficacy of the accelerated protocols for vessel wall imaging.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 15
• Est. completion date: July 2028
• Est. primary completion date: June 2026
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 99 Years

Eligibility

Inclusion Criteria:

1. Patients 18 years of age and scheduled to undergo clinical vessel wall MR imaging exams as part of their standard of care.

Exclusion Criteria:

1. Any person under the age of 18

2. Presence of artifact-producing intracranial devices (aneurysm clips/coils, ventricular drains, craniectomy mesh, etc.)

3. Any person with contraindications to MRI (medical instability, non-MRI compatible implanted devices, retained metallic foreign bodies, claustrophobia)

4. Large space-occupying lesions (50 mL) or substantial mass effect (herniation, 5mm midline shift) on preceding brain imaging,

5. Imminently life-threatening co-morbid conditions

6. A history of premorbid disabling neurological or psychiatric disease, current substance abuse or remote substance abuse with permanent organic sequelae

7. Pregnancy or lactation

Related Conditions & MeSH terms

• Vascular Diseases
• Vasculopathy

Locations

Country	Name	City	State
United States	Hospital of the University of Pennsylvania	Philadelphia	Pennsylvania
United States	University of Pennsylvania Hospital	Philadelphia	Pennsylvania

Sponsors (1)

Lead Sponsor	Collaborator
University of Pennsylvania

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Optimizing scan efficiency of T1-weighted (T1w) imaging for vessel wall imaging protocols	The primary outcome of the study will be the raters study where qualitative imaging scores will be provided by experienced radiologists using a four-point scale.	24 months