Longitudinal Study for Relapsing Polychondritis

Status Recruiting

Clinical Trial Summary

Clinical Trial Description

Relapsing polychondritis (RP) is a rare systemic inflammatory disease characterized by recurrent inflammation of cartilage including ears, nose, tracheobronchial tree, chest wall and joints. Less commonly, it can cause inflammation of eyes, vasculature, nervous system, skin and inner ear. There is variability in organ-system involvement and the disease course is relapsing making the diagnosis challenging. Delay in diagnosis can lead to end-organ damage and significant morbidity and mortality. There are no biomarkers or blood tests that can assist with assignment of a diagnosis. Development of this longitudinal cohort and multicenter approach offers the potential to generate new insights and generate new questions regarding the immunology of the disease. Attainment of a better understanding of the mechanisms and trajectory of inflammation may yield insights into potential new diagnostic and treatment strategies. Study visits will occur every 6 months, or annually. Blood and urine collection will occur at every visit. A physical exam and medical and medication history will at every visit; also, participants will be asked to complete several questionnaires to assess disease activity, health status, and tobacco, alcohol, and drug use. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04919538
Study type	Observational
Source	University of Pennsylvania
Contact	Carol McAlear
Phone	7813214567
Email	cmcalear@upenn.edu
Status	Recruiting
Phase
Start date	February 26, 2021
Completion date	January 2026

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