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Clinical Trial Summary

Overview:

This open label, randomized, multi-centre study will enroll and treat 24 patients with refractory AAV.

Aims:

To determine the clinical response and severe adverse event rates associated with alemtuzumab therapy among patients with relapsing or refractory ANCA associated vasculitis (AAV).

Hypothesis:

Treatment with alemtuzumab induces sustained remission in AAV and will reduce immunosuppressive and steroid exposure.


Clinical Trial Description

n/a


Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT01405807
Study type Interventional
Source Cambridge University Hospitals NHS Foundation Trust
Contact David RW Jayne, MD FRCP
Phone 00441223586796
Email dj106@cam.ac.uk
Status Recruiting
Phase Phase 4
Start date February 2011
Completion date March 2014

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