Clinical Trials Logo
  1. Home
  2. Vascular Disease
  3. NCT02244385

Manchester Antenatal Vascular Service — MAViS  

Vascular Disease Clinical Trial

Official title:
Manchester Antenatal Vascular Service

Clinical Trial Summary

25-30% of women with preexisting vascular disease (chronic hypertension/diabetes/obesity) will develop pre-eclampsia and or growth restriction. In addition, the frequency of stillbirths in this group is dramatically increased over the general population. Pregnancy complications in this very heterogeneous group are likely to be a combination of a failure of the maternal vasculature to adapt to pregnancy and/or a failure of placental development. The relative contribution of these two mechanisms is poorly understood and current preventative strategies (aspirin) in this group only prevent a small number of adverse outcomes. This important and complex group have been inadequately investigated to date mainly because of the diversity of their underlying disease complicating prospective research studies.

The evolution of tools which allow more detailed assessments of both uteroplacental blood flow and maternal vascular function will enable us to perform prospective studies in these women and to develop targeted preventative measures. Recent biomarker studies have also identified a number of biomarkers which have not yet been assessed in these high risk groups.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02244385
Study type Observational
Source Manchester University NHS Foundation Trust
Contact
Status Completed
Phase
Start date July 2011
Completion date December 2017
View Details
See also
  Status Clinical Trial Phase
Completed NCT01205776 - EXCEL Clinical Trial N/A
Completed NCT02542267 - In-Stent Restenosis Post-Approval Study N/A
Completed NCT01608035 - Sciatic Perineural Versus Stump Catheter for Below Knee Amputation Phase 0
Completed NCT00987181 - Non-Contact Measurement of Aortic Compliance N/A
Completed NCT01182428 - XIENCE V: SPIRIT WOMEN Sub-study Phase 4
Completed NCT00865124 - Role of Mineralocorticoid Receptor in Diabetic Cardiovascular Disease N/A
Completed NCT00759681 - ArterX Surgical Sealant, A Randomized Prospective Multicenter Trial Phase 3
Completed NCT00633659 - Pilot Study of Hemospan® in Patients With Chronic Critical Limb Ischemia Phase 2
Completed NCT00341562 - Genomics of In-Stent Restenosis N/A
Completed NCT00110604 - The Effect of Folic Acid on Atherosclerosis, Cognitive Performance and Hearing N/A
Completed NCT01355406 - Evaluation of Safety and Efficacy of the FlexStent® Femoropopliteal Self-Expanding Stent System N/A
Not yet recruiting NCT02843854 - Safety and Efficacy of Allogeneic MSCs in Promoting T-regulatory Cells in Patients With Small Abdominal Aortic Aneurysms Phase 1
Completed NCT01229358 - Clinical Trial of a Silver Eluting Dressing System Phase 4
Completed NCT01205789 - EXCEL Clinical Trial (Universal Registry) N/A
Completed NCT01221610 - BIOLUX P-I First in Man Study N/A
Recruiting NCT01358630 - Vascular and Periodontal Disease - Microbial, Genetic and Histological Causalities N/A
Completed NCT00805831 - Safety and Efficacy of Using HDH Device and Method - a Novel Sutureless Vascular Anastomosis N/A
Completed NCT00782015 - Effects of Almonds on Vascular Reactivity in Patients With Coronary Artery Disease N/A
Withdrawn NCT00334724 - Home Blood Pressure-guided Antihypertensive Intervention for Elderly (HBP-GUIDE) Study Phase 4
Active, not recruiting NCT02751099 - Bone and Cardiovascular Disease After Kidney Transplant