Vascular Disease Clinical Trial
Official title:
Genomics of In-Stent Restenosis: Endarterectomy Study
This study, conducted in Argentina at the Hospital Espa ol de la Plata and the Hospital
Franc s de Buenos Aires, in collaboration with the NHLBI, will investigate possible genetic
factors that lead to in-stent restenosis. A stent is a wire mesh tube that is surgically
placed to open a blocked artery. The stent stays in the artery permanently, holding it open
to improve blood flow. In the case of blocked coronary arteries, the stent improves blood
flow to the heart muscle, relieving symptoms such as chest pain and shortness of breath.
Sometimes re-growth of tissue within a stent, called in-stent restenosis, leads to narrowing
of the artery, decreased blood flow, and a recurrence of symptoms. Genetic analysis may
allow the identification of patient that may be at increased risk for in-stent restenosis
and lead to methods of prevention and treatment.
Patients 18 years of age and older who are undergoing coronary endarterectomy (surgery to
remove plaque from an artery) to treat in-stent restenosis at the Hospital Espa ol de la
Plata and the Hospital Franc s de Buenos Aires may be eligible for this study.
Participants will have a blood sample drawn and undergo coronary endarterectomy. Tissue
removed from the patient's artery or the stent during surgery will be analyzed for gene
expression profiling and genotyping. The results will be studied along with information
about the patients' medical history.
Status | Completed |
Enrollment | 30 |
Est. completion date | July 2006 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
- INCLUSION CRITERIA Patients 18 years of age or older Patients undergoing coronary endarterectomy as part of their course of medical therapy. The lesion for which endarterectomy is being performed is restenosis within a bare metal stent within a native coronary artery EXCLUSION CRITERIA Current enrollment in a clinical trial for the treatment or prevention of in-stent restenosis. Lesion within saphenous vein graft following coronary artery bypass grafting Patients younger than 18 years of age The patient is unable to provide informed consent |
N/A
Country | Name | City | State |
---|---|---|---|
United States | National Heart, Lung and Blood Institute (NHLBI) | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Heart, Lung, and Blood Institute (NHLBI) |
United States,
Hayashi S, Watanabe N, Nakazawa K, Suzuki J, Tsushima K, Tamatani T, Sakamoto S, Isobe M. Roles of P-selectin in inflammation, neointimal formation, and vascular remodeling in balloon-injured rat carotid arteries. Circulation. 2000 Oct 3;102(14):1710-7. — View Citation
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