Clinical Trials Logo
  1. Home
  2. Vascular Complications
  3. NCT05217654

Trial to Investigate the Effect of Dapagliflozin on Ischemia Reperfusion Induced Endothelial Dysfunction

Reperfusion Injury Clinical Trial

Official title:
A Randomized, Double - Blind, Placebo - Controlled Trial to Investigate the Effect of Dapagliflozin on Ischemia Reperfusion Induced Endothelial Dysfunction of the Forearm Vasculature in Healthy Male Subjects

Clinical Trial Summary

The aim of the study is to investigate the effect of dapagliflozin or placebo on acetylcholine (Ach)- or nitroglycerin (GTN)-induced vasodilation of the forearm resistance vasculature, as determined by FBF measurement before and 10 minutes after 20 minutes of forearm ischemia.

Clinical Trial Description

The aim is to test the effect of dapagliflozin or placebo on ACh-induced vasodilatation of the forearm resistance vasculature as assessed by FBF measurement before and 10 min after a 20 min forearm ischemia as well as after a 14 day treatment period. The area under the dose-effect curve (AUC) of different ACh doses will be calculated and compared between treatment groups (dapagliflozin vs. placebo) and different time points (pre-ischemia vs. post-ischemia). FBF measurements will be made in response to increasing intra-arterial doses of ACh (25, 50, 100 nmol/min) to assess endothelial function or GTN (4, 8, 16 nmol/min) to test vascular smooth muscle vasodilator function. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05217654
Study type Interventional
Source Medical University of Vienna
Contact Martin Lutnik, M.D.
Phone +43 1 40400
Email martin.lutnik@meduniwien.ac.at
Status Recruiting
Phase Phase 1
Start date February 18, 2022
Completion date August 1, 2023
View Details
See also
  Status Clinical Trial Phase
Completed NCT02251041 - Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL) Phase 2
Completed NCT01944605 - Intestinal Ischemia as a Stimulus for Systemic Inflammatory Response After Cardiac Arrest N/A
Completed NCT00994981 - Magnesium Administration in Liver Transplantation and Reperfusion Injury Phase 4
Completed NCT00529607 - Diagnostics for the Reperfusion Injury Following MI N/A
Completed NCT00778323 - Clinical Trial of Remote Preconditioning in Patients Undergoing Cervical Decompression Surgery Phase 1/Phase 2
Completed NCT02286544 - Effects of Oxygen Treatment on Mechanisms Involved in Ischemia-reperfusion Injury: A Pilot Study in Healthy Volunteers Phase 1
Completed NCT02731651 - Effect of Pneumoperitoneum on Human Ovary N/A
Active, not recruiting NCT00189007 - Antenatal Allopurinol During Fetal Hypoxia Phase 3
Completed NCT01167569 - Study of High Dose Vitamin C On Outcome in Cardiac Surgery Patients Phase 4
Completed NCT00246740 - Protection of the Heart With Doxycycline During Coronary Artery Bypass Grafting Phase 2
Enrolling by invitation NCT05725694 - Acute Ischaemic STROKE: From LAboratory to the Patient's BED
Completed NCT00402506 - A Safety and Efficacy Study to Confirm the Cardioprotective Effects of MC-1 in Patients Undergoing High-Risk CABG Phase 3
Completed NCT03176823 - Remote Ischemic Conditioning as a Treatment for Traumatic Brain Injury N/A
Completed NCT02512640 - Comparison of Oxidative Stress Changes in Different Ventilation Strategies During Gynecologic Laparoscopic Surgery N/A
Recruiting NCT05574296 - Hydrogen's Feasibility and Safety as a Therapy in ECPR Phase 1
Active, not recruiting NCT02127996 - GLP-1 Loading During Elective Percutaneous Coronary Intervention Phase 2
Terminated NCT02394405 - Myocardial and Renal Dysfunction by Oxidative Stress Caused by Cardiac Surgery
Suspended NCT02850471 - Pulmonary Protection of Transcutaneous Electrical Acupoint Stimulation in Gynecologic Laparoscopic Surgery Phase 1/Phase 2
Completed NCT00516711 - Role of Volatile Anesthetics for Hepatic Protection N/A
Terminated NCT04316468 - Cardiac Strain Using Speckle Tracking Echocardiography During Orthotopic Liver Transplantation