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Prevention of the Progression of Coronary Calcification With Use of Spironolactone in Peritoneal Dialysis Patients

Coronary Artery Calcification Clinical Trial

Official title:
Effect of Spironolactone on the Progression of Coronary Calcification in Peritoneal Dialysis Patients

Clinical Trial Summary

Vascular calcification is a frequent complication in dialysis patients and is strongly associated with mortality. Its pathogenesis is complex and involves a series of markers that act on the vascular microenvironment. There is evidence that aldosterone is one of the biomarkers and may have a role in osteoinductive pathways.The aim of this study was to evaluate the effect of spironolactone, an inhibitor of mineralocorticoid receptor, in the progression of coronary calcification in patients undergoing peritoneal dialysis.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03314493
Study type Interventional
Source Professor Fernando Figueira Integral Medicine Institute
Contact
Status Completed
Phase Phase 3
Start date November 7, 2014
Completion date November 10, 2016
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