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Varicose Veins of Lower Limb clinical trials

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NCT ID: NCT06387264 Active, not recruiting - Clinical trials for Varicose Veins of Lower Limb

Compont - Varicose Veins of the Lower Extremities

Start date: January 11, 2023
Phase: N/A
Study type: Interventional

The purpose of this clinical trial is to evaluate the effectiveness and safety of Medical Adhesive produced by Beijing Compont Medical Devices Co., Ltd. in the treatment of varicose veins in the lower extremities. The main questions it aims to answer is: What medical problems do participants have when using tissue glue? Researchers will compare Medical Adhesive to ClosureFast Endovenous Radiofrequency Ablation (RFA) Catheter (produced by Medtronic Inc. to see if Medical Adhesive works to treat varicose veins in the lower extremities. Participants will: Treated with closed varicose veins of the lower extremity by Medical Adhesive or ClosureFast. Return to the hospital at 1, 12, and 24 weeks postoperatively for Doppler ultrasound, and at 4, 12, 24 weeks postoperatively for venous scoring.

NCT ID: NCT06367166 Active, not recruiting - Vascular Diseases Clinical Trials

Effects of Bioflavanoids on Vascular Wall Remodeling in Patients With Varicose Veins

Start date: April 1, 2023
Phase: N/A
Study type: Interventional

The study is aimed at assessing the dynamics of changes in biochemical markers of venous wall remodeling (type 1 plasminogen activation inhibitor (PAI-1), fibronectin (fibronectin, FN), vimentin (vimentin, VM), von Willebrand factor (vWF), PECAM-1 (CD31) ) in patients with C2s-C3s varicose veins compared with healthy volunteers while taking Venarus® (diosmin in combination with hesperidin).

NCT ID: NCT06366763 Recruiting - Clinical trials for Varicose Veins of Lower Limb

Comparative Clinical Efficacy Between Multi-layer Bandage Pressure Therapy and Gradient Pressure Elastic Stocking Treatment After Endovenous Radiofrequency Ablation

Start date: August 1, 2023
Phase: N/A
Study type: Interventional

Objective: To assess the clinical efficacy of different compression methods within 48 hours after endovenous radiofrequency ablation (RFA) in terms of great saphenous vein closure rate, postoperative complications, quality of life, time to return to normal work, and patient satisfaction.

NCT ID: NCT06175546 Enrolling by invitation - Clinical trials for Chronic Venous Insufficiency

Daily Duration of Compression Treatment in Patients With Symptomatic Chronic Venous Disease

Start date: February 15, 2023
Phase: N/A
Study type: Interventional

Aim of study is to investigate the optimal duration and daily regimen of compression treatment in patients with chronic venous disease

NCT ID: NCT06124664 Recruiting - Clinical trials for Varicose Veins of Lower Limb

Study of Venous Outflow From the Lower Limbs in Patients With Pelvic Varicosities

Start date: May 4, 2023
Phase:
Study type: Observational

Compression therapy is basic treatment for chronic venous disease (CVD) of the lower limbs. Numerous studies have demonstrated the efficacy and safety of compression therapy in relieving symptoms such as pain, venous edema, leg heaviness and fatigue, as well as accelerating the healing of venous ulcers. It has been established that сompression therapy is indicated for patients with both minimally expressed manifestations of CVD and severe forms of the disease. At the same only one study has been conducted to assess the correction of venous outflow from the lower limbs and pelvis in patients with pelvic varicose vein (PVV) and pelvic congestion syndrome (PCS). However, the incidence of this pathology ranges from 15 to 30% in the female population. The cost to the healthcare system of treating these patients in the United States exceeds $2 billion. To date, the options and indications for compression therapy in patients with concomitant PVV and CVD have not been defined. The rational use of compression in this cohort of patients may contribute to the improvement of effective conservative treatment. In addition, inappropriate prescription of compression to patients with pelvic venous disease (which can be observed in real clinical practice) may discredit this simple, effective and safe therapeutic method. In addition, the research devoted to the problem of compression treatment of PVV will contribute to the development of new special compression products aimed at accelerating venous outflow from the pelvic organs. It can be assumed that this will serve as a stimulus for obtaining new data on the therapeutic effects of compression and create conditions for the creation of new technological directions in the production of compression knitwear.

NCT ID: NCT05978986 Recruiting - Clinical trials for Varicose Veins of Lower Limb

Efficiency of Determining the Clinical Class of Chronic Venous Disorders by Artificial Intelligence

IVENUS
Start date: August 25, 2023
Phase: N/A
Study type: Interventional

Purpose: To evaluate the sensitivity and specificity of the method for determining the clinical class of chronic venous diseases using the Ivenus application (within C0-C2 according to CEAP). Materials and methods: Patients who applied to several phlebology clinics for an initial consultation are consistently included in a multicenter prospective study. At the appointment, a doctor with at least 5 years of experience takes photographs of the lower extremities and uploads them to the IVENUS application, which automatically determines the clinical class according to CEAP, without showing the results to the surgeon (blinding). Further, the doctor independently determines the clinical class according to CEAP and enters the data into the register. The object of the study is a photograph of a certain area of the lower limb.

NCT ID: NCT05930587 Not yet recruiting - Clinical trials for Varicose Veins of Lower Limb

Effect of Cold Immersion on Patients With Varicose Vein

Start date: September 25, 2023
Phase: N/A
Study type: Interventional

In the literature, it is stated that cold water immersion to lower extremities is effective on the symptoms of the disease. Studies have shown that cold water immersion, which is one of the cold application methods, has effects on increasing joint mobility, reducing pain, reducing stress, anxiety, depression, and increasing quality of life etc. For this reason, the study is planned as a randomized controlled interventional study to determine the effect of cold water immersion directly to the lower extremity in the preoperative period of patients with varicose veins on quality of life, anxiety and symptoms experienced.

NCT ID: NCT05914740 Recruiting - Clinical trials for Varicose Veins of Lower Limb

Feasibility Study of Ultrasound-guided Functional Remodeling of Lower Extremity Superficial Venous Valve

Start date: April 19, 2023
Phase: N/A
Study type: Interventional

In this project, an exploratory study was conducted to perform in situ venous valve remodeling in vivo, evaluate venous valve function after surgery and conduct regular follow-up, collect relevant ultrasonic data before, during and after surgery, and evaluate the safety and effectiveness of Ultrasound-guided percutaneous great saphenous vein valve functional remodeling.

NCT ID: NCT05851183 Recruiting - Clinical trials for Varicose Veins of Lower Limb

Effect of Vitis Vinifera Seed Extract on Venous Reflux Time in Varicose Vein

VICTORY
Start date: July 20, 2023
Phase: Phase 4
Study type: Interventional

The number of patients with lower extremity varicose veins has been increasing due to an aging population, with treatments divided into conservative and invasive methods. Current treatments can be expensive and inaccessible for some patients. Entelon, a relatively inexpensive intravenous drug, has shown promise in improving symptoms related to venous lymphatic dysfunction, but its objective vascular function improvement hasn't been proven. This study aims to assess the effectiveness of Vitis Vinifera seed extract (Entelon®) combined with lifestyle therapy in patients with varicose veins, using follow-up Doppler ultrasonography to measure venous reflux improvement.

NCT ID: NCT05654233 Not yet recruiting - Clinical trials for Varicose Veins of Lower Limb

The Study of Reducing Adverse Effects After Radiofrequency Ablation Combined With Sclerotherapy

Start date: February 1, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate whether adding sulodexide to the patients with varicose veins who received radiofrequency ablation combined with sclerotherapy can reduce or improve the impact of adverse events。