Variceal Bleeding Clinical Trial
Official title:
Effect of Intravenous Bolus Infusion of Erythromycin Prior to Endoscopy in Patients Presenting With Variceal Bleeding: A Prospective, Randomized, Double- Blind ,Placebo Controlled, Trial
Objectives:
Blood in stomach & oesophagus in patients with variceal bleeding often obscures the
endoscopic view & makes endoscopic intervention difficult to perform. Erythromycin, a
motilin agonist induces gastric emptying. The aim of this study was to assess the effect of
Erythromycin on endoscopic visibility and its outcome.
Methods:
Adult patients with liver cirrhosis or stigmata of chronic liver disease presenting with
hematemesis and or melena within previous 12 hours were randomized in a double blind trial
to receive either 125 mg erythromycin or placebo 30 minutes before endoscopy. The primary
end points were endoscopic visibility assessed by objective scoring system & mean endoscopy
duration. Secondary end points were need for repeat endoscopy and blood transfusions within
24 hours of first endoscopy , endoscopy related complications and length of hospital stay.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT00965900 -
Endoscopic Band Ligation (EBL) Versus Propranolol for Primary Prophylaxis of Variceal Bleeding
|
Phase 4 | |
| Recruiting |
NCT05629845 -
Prevention of Variceal Rebleeding by EUS-guided vs Conventional Endoscopic Therapy in Hepatocellular Carcinoma Patients
|
N/A | |
| Completed |
NCT00570973 -
Band Ligation Versus Transjugular Intrahepatic Portosystemic Stent Shunt (TIPS) in Cirrhotics With Recurrent Variceal Bleeding Non Responding to Medical Therapy
|
Phase 4 | |
| Recruiting |
NCT00562445 -
Adrenal Insufficiency in Critical Emergencies in Digestive Diseases
|
N/A | |
| Terminated |
NCT01383044 -
Banding Ligation With Carvedilol Versus Carvedilol for the Prevention of First Bleeding
|
Phase 4 | |
| Completed |
NCT00921349 -
A Trial of Ligation Plus Nadolol Versus Nadolol Alone in the Prophylaxis of First Variceal Bleeding in Cirrhosis
|
Phase 4 | |
| Recruiting |
NCT00966121 -
Endoscopic Band Ligation (EBL) Versus Endoscopic Band Ligation and Propranolol for the Prevention of Variceal Rebleeding
|
Phase 4 | |
| Recruiting |
NCT00966082 -
EBL Versus EBL and Propranolol for the Prevention of Variceal Rebleeding in Pts With Previous Variceal Treatment
|
Phase 4 | |
| Completed |
NCT01291277 -
Time Interval for Endoscopic Variceal Ligation
|
Phase 4 |