Variceal Bleeding Clinical Trial
Official title:
Effect of Intravenous Bolus Infusion of Erythromycin Prior to Endoscopy in Patients Presenting With Variceal Bleeding: A Prospective, Randomized, Double- Blind ,Placebo Controlled, Trial
Objectives:
Blood in stomach & oesophagus in patients with variceal bleeding often obscures the
endoscopic view & makes endoscopic intervention difficult to perform. Erythromycin, a
motilin agonist induces gastric emptying. The aim of this study was to assess the effect of
Erythromycin on endoscopic visibility and its outcome.
Methods:
Adult patients with liver cirrhosis or stigmata of chronic liver disease presenting with
hematemesis and or melena within previous 12 hours were randomized in a double blind trial
to receive either 125 mg erythromycin or placebo 30 minutes before endoscopy. The primary
end points were endoscopic visibility assessed by objective scoring system & mean endoscopy
duration. Secondary end points were need for repeat endoscopy and blood transfusions within
24 hours of first endoscopy , endoscopy related complications and length of hospital stay.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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