Post-surgical Aortic Hemodynamics After Aortic Valve Replacement

Status Completed

Clinical Trial Summary

The purpose of this pilot study is to obtain both near valve and downstream flow characteristics, using 3D transthoracic echocardiography and 4D flow MRI respectively, in an existing patient population at Northwestern Memorial Hospital, to determine the hinge washout characteristics and downstream flow patterns of the On-X valve and compared to competing designs.

Clinical Trial Description

Prospective, concurrent 4D flow Magnetic Resonance Imaging (MRI) and echocardiography of On-X and St Jude Medical (SJM) Masters HP or Carbomedics Carbo-seal or Carbo-seal Valsalva aortic valve replacement (AVR) patients will be performed. Echocardiography analysis will include: valve function (opening angle), pressure gradients, and degree of valve washout. MRI analysis will focus on downstream flow patterns (helicity and vorticity), energy loss, pressure recovery, and measurement of wall shear stress in the anastomosis regions. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03347851
Study type	Observational
Source	CryoLife, Inc.
Contact
Status	Completed
Phase
Start date	October 26, 2017
Completion date	June 1, 2020

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT06066970` - Cardiac Biomarkers for the Quantification of Myocardial Damage After Cardiac Surgery
Recruiting	`NCT05079672` - Efficacy and Safety of Dexmedetomidine in the Analgesic Prophylaxis , in Patients Undergoing Cardiovascular Surgery	Phase 4
Active, not recruiting	`NCT03539458` - Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification	N/A
Completed	`NCT04328090` - Evaluation of the Potential Impact of Computerized Antimicrobial Stewardship	N/A
Recruiting	`NCT04359030` - Freestyle-Perimount Calcification Comparison
Completed	`NCT04958668` - Prospective Evaluation of Volatile Sedation After Heart Valve Surgery	N/A
Completed	`NCT04598360` - Release of Epoxyeicosatrienoic Acids From Erythrocytes During the Use of Extracorporeal Procedures (Heart-lung Machine)	N/A
Not yet recruiting	`NCT04118621` - Role of Chest Ultrasound in Detection of Post-operative Pulmonary Complications After Cardiothoracic Surgery
Recruiting	`NCT06387446` - Allogeneic Valve Transplantation	N/A
Recruiting	`NCT04843072` - Balloon vs. Self Expanding Transcatheter Valve for Degenerated Bioprosthesis	N/A
Completed	`NCT05804500` - RecoveryPlus Telerehab Platform Pilot Study	N/A
Recruiting	`NCT03885180` - Randomized Evaluation of D-dimer Guiding dUration of Oral antiCoagulation thErapy	N/A
Completed	`NCT06154018` - Heparin Reversal With Two Different Protamine Ratios After Cardiopulmonary By-pass.	N/A
Recruiting	`NCT06041308` - Bioprothetic Valve Versus Mechanical Valve of Bioprothetic Valve Versus Mechanical Valve
Suspended	`NCT01571791` - Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery	Phase 2
Completed	`NCT06261788` - Efficacy and Safety of the Sync-AV II Temporary Cardiac Pacing Catheter	N/A
Completed	`NCT06079008` - The Association of Cardiac Valve Calcification and 1-year Mortality After Lower-extremity Amputation in Diabetic Patients
Completed	`NCT04372654` - Pilot Study Evaluating the Safety of Electroducer Sleeve Medical Device for Temporary Cardiac Stimulation During Percutaneous Cardiovascular Interventions, in All Kind of Patients	N/A
Active, not recruiting	`NCT03661398` - Caisson Transcatheter Mitral Valve Replacement (TMVR)	N/A
Recruiting	`NCT03595423` - SPAnish Aortic VALVE Multicentric Study