Intact Vagal Innervation for and Glucagon-like Peptide-1 (GLP-1) Effects

Vagotomy, Truncal Clinical Trial

Official title: The Significances of Intact Vagal Innervation for the Glucose and GLP1 Induced Insulin Secretion

Status Active, not recruiting

Clinical Trial Summary

The aim of this study is to investigate the role of transmission via the vagal nerve for the effect of glucose and Glucagon-like peptide-1 (GLP-1) in respect to insulin secretion.

The hypothesis is that a great deal of the effects of GLP-1 is mediated via the nervous system and for this reason the investigators will research individuals with and without intact nervous supply.

Clinical Trial Description

GLP-1 is a potent enterogastron and incretin hormone. It is rapidly inactivated by dipeptidyl peptidase IV so only 10-15% enters the systemic circulation. This has led to the hypothesis that GLP-1 interact locally with afferent sensory nerve fibers. We investigated the role of intact vagal innervations on the effect of glucose and GLP-1 on the insulin secretion ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Vagotomy, Truncal

• NCT number: NCT01176760
• Study type: Interventional
• Source: University Hospital, Gentofte, Copenhagen
• Status: Active, not recruiting
• Phase: N/A
• Start date: August 2009
• Completion date: December 2012