Vaginitis Clinical Trial
Official title:
Establishment of a Sensitive System for Analysis of Child-bearing Women Vaginal Microbiota Which Overall Evaluation of Microscopic Precision Reference Standards
The vaginal microbiota is an important biological barrier for host against pathogens or
opportunistic pathogens. Undermining the balance of the vagina is closely related to
infectious diseases and tumors.
The vaginal microbiota of child-bearing women of age is dominated by Lactobacillus species,
including major four species: Lactobacillus crispatus, Lactobacillus jensenii, Lactobacillus
gasseri and Lactobacillus iners, followed by obligate anaerobes such as Gardnerella
vaginalis, Atopobium vaginae, Mobiluncus curtisii, and Prevotella .
Currently, There are almost 99% bacteria can not to be found with bacterial culture. Based
on microscopy and conventional culture method to obtain vaginal microflora information have
a variety of deviation. For this reason, The in-depth study of complex vaginal flora and the
correct understanding of disease faces a serious obstacle. With the development of
High-throughput sequencing technology， metagenomics can get all the composition and
distribution of microorganisms from the sample which traditional knowledge may not be with
microorganism culture method. Therefore, Re-evaluation of existing microflora diagnostic
criteria for clinical diagnosis of the disease is necessary.
In this study, the investigators use high-throughput sequencing technology to detect women
of childbearing age vaginal microflora of metagenomic distribution. Including bacteria,
fungi, viruses, protozoa, and other microorganisms. Based on the study results of
metagenomic, the investigators want to re-cognition the"normal flora"of women of
childbearing age ,and develop vaginal microflora microscopic evaluation of the integrity of
the reference standard.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02515656 -
Assessment of the Efficacy of POLYGYNAX® in the Empirical Treatment of Infectious Vaginitis
|
Phase 3 | |
| Recruiting |
NCT01420510 -
Saginil in vs. Placebo for Gynecologic Oncology Patients Affected by Vaginitis
|
Phase 2/Phase 3 | |
| Completed |
NCT04079218 -
Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial
|
Phase 4 | |
| Recruiting |
NCT05557318 -
Using Micro Electro Mechanical Systems to Detect the Air of Vaginal Discharge
|
N/A | |
| Completed |
NCT01436513 -
A Study To Compare The Amount Of Premarin Components That Is Absorbed Into The Blood Of Japanese Healthy Postmenopausal Women Following Oral Administration Of Two Different Tablets Of Premarin Under Fast and Fed Conditions.
|
Phase 1 | |
| Completed |
NCT03585049 -
Microscopic Images for the Development of a Rapid Vaginitis Diagnostic Device
|
||
| Completed |
NCT04676503 -
Vaginal and Rectal Colonization of Lactobacillus Crispatus NTCVAG04 Following Oral Administration in Patients With History of Vaginitis/Vaginosis
|
N/A | |
| Completed |
NCT02641717 -
Validity of Patient-Collected Wet Mounts
|
N/A | |
| Recruiting |
NCT05587283 -
Safety, Tolerability, and Acceptability Study of Intravaginal Administration of LABTHERA-001 Capsules in Healthy Women
|
Phase 1 | |
| Not yet recruiting |
NCT06070454 -
Prospective Evaluation of Infectious Vulvovaginitis on Wound Complication Rates After Vulvar Excision for Premalignant Lesions
|
N/A | |
| Completed |
NCT02365389 -
Once Daily In-situ Forming Versus Twice-daily Conventional Metronidazole Vaginal Gels for Treatment of Bacterial Vaginosis
|
Phase 2/Phase 3 | |
| Completed |
NCT01050465 -
MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use
|
N/A | |
| Completed |
NCT05652959 -
Real-world Performance and Safety of Cerviron® in the Treatment of Vaginitis
|
||
| Recruiting |
NCT04574089 -
Treatment for Aerobic Vaginitis by Using Bofukang Vaginal Suppository
|
Phase 3 | |
| Recruiting |
NCT04816903 -
Gyni™ Study With Leumit Health Services
|
N/A | |
| Completed |
NCT05670535 -
Sjögren and Gynecologic Considerations
|
||
| Enrolling by invitation |
NCT04984460 -
Morphological Detection of Liquid-based Thin-layer Film-making Fungi for Fungal Vaginitis in Multiple Hospitals
|
||
| Completed |
NCT03151928 -
Diagnostic Accuracy By Providers Study
|
||
| Completed |
NCT05396261 -
a Flexible Wound Dressing for the Management of Genital Skin Conditions
|
N/A | |
| Completed |
NCT00803127 -
VS-Sense Result Reading Clarity
|
N/A |