Vaginal Flora Imbalance Clinical Trial
Official title:
Effect of Chlorhexidine Gluconate Versus Povidone-iodine on the Vaginal Microbiome as Vaginal Operative Preparation During Gynecologic Surgeries
A hysterectomy, or removal of the uterus, is a common surgery performed for a variety of reasons. During this surgery, to prevent infection, the vagina is thoroughly prepped with a cleansing solution, most commonly chlorhexidine gluconate or povidone-iodine. While studies have shown that chlorhexidine gluconate is better at killing bacteria people have raised concerns on how it affects the vaginal tissue. It is important to study these effects the cleansing solution surgeons use for this surgery can not only prevent infection but not cause harmful side effects.
The purpose of this study is to examine the effects of different vaginal operative preparations on the vaginal tissue and microbiome. Our primary working hypothesis is that chlorhexidine prep is more deleterious to vaginal tissue than povidone-iodine preparations. Hypothesis 1: chlorhexidine gluconate is more disruptive to the vaginal microbiome than povidone-iodine Hypothesis 2: chlorhexidine gluconate leads to more vaginal atrophy than povidone-iodine ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03701893 -
Evaluate the Use of a New Probiotic Strain in Couples With Fertility Problems and Dysbiosis.
|
N/A | |
| Completed |
NCT05114031 -
FB101 Intervention in Women Screened to Have Vaginal Dysbiosis
|
N/A | |
| Recruiting |
NCT05640700 -
Vaginal Microbiome and HPV Pre-malignant and Cervical Dysplasia
|
||
| Not yet recruiting |
NCT06085898 -
Stryphnodendron Adstringens Intimate Soap
|
N/A | |
| Recruiting |
NCT05850078 -
FB101 Intervention in Women Screened to Have Vaginal Dysbiosis (Dyscover-3)
|
N/A | |
| Completed |
NCT04721938 -
Healthy Parents - Healthy Children. Weight Loss Before Fertility Treatment
|
N/A | |
| Recruiting |
NCT05150639 -
Vaginal Microbiome and IVF Pregnancy Outcome
|
||
| Completed |
NCT03843112 -
Modulating the Vaginal Microbiome After Implantation Failure
|
Phase 4 | |
| Recruiting |
NCT05808816 -
"Lactobacillus Crispatus M247, LSIL and Microbiota"
|
Phase 4 | |
| Recruiting |
NCT05573334 -
Vaginal Care System for Menopausal Women With Urinary Tract Infections
|
N/A | |
| Completed |
NCT03734523 -
Clinical Trial to Survey Results of Flourish Vaginal Care System for Recurrent Bacterial Vaginosis
|
||
| Completed |
NCT04171947 -
Vaginal Ovule With Flavonoid Tea Extract for the Correction of Imbalance in the Vaginal Environment
|
N/A | |
| Recruiting |
NCT04202302 -
Vaginal Profile in IVF/ICSI and Impact on Clincal Outcome
|