Clinical Trials Logo
  1. Home
  2. Vaginal Delivery
  3. NCT00802646

The Effects of Combined Spinal Epidurals on Fever During Labor of First-Time Mothers — CSE  

Vaginal Delivery Clinical Trial

Official title:
Randomized, Double-Blind, Placebo-Controlled Study of Effects of Combined Spinal Epidural Analgesia on Intrapartum Fever.

Clinical Trial Summary

The purpose of this study is to determine if the epidural of local anesthetics has an effect on fever that may occur in first time mothers during labor.

Clinical Trial Description

Intrapartum fever (fever during labor) is a real and potentially devastating problem. Infants delivered at term who have been exposed to the mother having a fever during labor have a >9 fold increased risk of cerebral palsy. Studies have also shown an increased risk of neonatal encephalopathy associated with fever during labor. Maternal fever in the absence of infection is associated with a 4 fold increased risk of neonatal hypoxic encephalopathy and 3.4 fold increased risk of unexplained neonatal seizures. The likely role of inflammatory mediators in the process of maternal fever (temperature >100.4), regardless of etiology, makes it important to further investigational studies in an effort to discover the etiology of intrapartum fever associated with epidural analgesia. If an inflammatory trigger (i.e., the injection of epidural local anesthetics) can be identified or delayed, then the risks of maternal hyperthermia can be minimized and/ or eliminated. The greatest risk of fever with epidural labor analgesia is seen in women having their first child. This is the same population associated with prolonged labor. Although intrapartum fever has a very low incidence overall, 11-33% of first-time mothers will eventually develop fever >100.4 during epidural analgesia. Although the degree of rise in temperature occurs very slowly, it has been shown to be significant enough to cause increased neonatal sepsis workup and antibiotic coverage for both the mother and the neonate. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00802646
Study type Interventional
Source Ochsner Health System
Contact
Status Withdrawn
Phase N/A
Start date June 2009
Completion date June 2010
View Details
See also
  Status Clinical Trial Phase
Completed NCT06126328 - Materna Prep Study Phase II Phase 2
Not yet recruiting NCT05501106 - Reducing Postpartum Hemorrhage After Vaginal Delivery N/A
Completed NCT05429580 - Prophylactic Tranexamic Acid Use After Vaginal Delivery N/A
Completed NCT05786911 - Postpartum Fatigue and Pain Versus Nutritional Status, With Epidural Analgesia
Completed NCT05371015 - Quadratus Lumborum Block Reduced Postpartum Uterine Pain After Virginal Childbirth N/A
Not yet recruiting NCT06202768 - Role of the Intrapartum Grobman Nomogram in the Indication of Attempted Vaginal Delivery After Cesarean Section
Terminated NCT04277962 - Estimating Blood Loss Using TritonTM in Vaginal Deliveries: A Validation Trial N/A
Terminated NCT04004845 - Labor Protocol Study
Not yet recruiting NCT05247073 - Mostafa Maged Four-stitch Technique in Closure the Episiotomy During Vaginal Delivery N/A
Recruiting NCT00407290 - The Impact of an Epidural Ropivacaine-Neostigmine Injection for Perineal Analgesia at the End of Labor. N/A
Terminated NCT01190163 - Open Label Comparative Trial of Dinoprostone Plus or Minus Oxytocin Versus Oxytocin Alone in Cervical Ripening for Labor Induction Phase 4
Completed NCT03903172 - Post-partum Non-pharmacologic Pain Management N/A
Recruiting NCT04955847 - Efficacy and Safety of Oral Misoprostol 25 μg vs. Vaginal Dinoprostone in Induction of Labor at Term
Completed NCT02824679 - Effect of Intravenous Hyoscine Butylbromide Injection on First Stage Labour in Primigavidae Phase 4
Completed NCT03264599 - Measurement of the Fetal Occiput-spine Angle During the First Stage of Labor as Predictor of the Outcome of Labor N/A
Completed NCT04543487 - Therapeutic Touch on Labour Pain, Anxiety and Childbirth Attitude N/A
Recruiting NCT02024256 - Cold Magnesium Sulfate Solution for Perineal Swelling Following Vaginal Delivery N/A
Recruiting NCT06426329 - The Effect of Therapeutic Touch at Birth on Pain, Birth Duration, Traumatic Birth Perception and Anxiety N/A
Not yet recruiting NCT06044129 - A Novel Approach Integrating Magnetic Resonance Imaging (MRI) Data and Artificial Intelligence for Predicting the Success Rate of Vaginal Delivery in Pregnant Women
Completed NCT03055390 - Effect of Intravenous Hyoscine Butylbromide Injection on Labour in High Risk Women Phase 4