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Clinical Trial Summary

Vaccines have prevented countless infections but poor vaccine responses remain a major challenge in many scenarios. Hepatitis B vaccine nonresponses are common but immunologically not well-understood. This study aims to study the immunology of hepatitis B vaccine responses by comparing traditional HBV vaccine, which is associated with nonresponses in some patients, to CpG-adjuvanted HBV vaccine, which is associated with far fewer rates of nonresponses. This research will build upon prior studies of the human immune response to infection to gain a deeper understanding of the complexity of these responses. This information will be broadly useful as many vaccine candidates fail due to lack of immunogenicity, potentially enabling improved vaccine design and better protection.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04674462
Study type Interventional
Source NYU Langone Health
Contact Ramin Herati, MD
Phone 646-477-9086
Email Ramin.Herati@nyulangone.org
Status Recruiting
Phase Phase 4
Start date July 7, 2022
Completion date September 2026

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