Vaccination Reaction Clinical Trial
Official title:
Impact of Early Antibiotic Therapy on Vaccination Response in Preterm Infants
Neonatal Sepsis is one of the most common causes of death in preterm infants. Therefore, up to 80% of very low birth weight infants receive antibiotic therapy in their first week of life. Antibiotic therapy is one of the most important influencing factors for the establishment of the intestinal microbiome, which in turn modulates neonatal immune development. In this pilot study, it will be investigated, if antibiotic therapy in the first week of life influences the vaccination response of preterm infants.
Status | Recruiting |
Enrollment | 20 |
Est. completion date | October 2021 |
Est. primary completion date | October 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 24 Weeks to 28 Weeks |
Eligibility |
Inclusion Criteria: - born at University Hospital Tübingen - at least one dose of antibiotics within the first week of life Exclusion Criteria: - genetic disorders - chronic infections - hematological disorders - immunoglobulins within the first 60 days of life - immunological disorders - infants from Hepatitis B positive mothers |
Country | Name | City | State |
---|---|---|---|
Germany | University Hospital | Tübingen | Baden-Württemberg |
Lead Sponsor | Collaborator |
---|---|
University Hospital Tuebingen |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | vaccination reaction | measurement of antibody titers for Hepatitis B, Polio, Pertussis, Haemophilus Influenza B, Tetanus, Diphteria and Pneumococcus 4 months after the first vaccination (at an age of 6 months) | 7 months | |
Secondary | Microbiome composition | microbiome analyses of stool samples at age 14 days and corrected 4 months | 7 months |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05043168 -
Kidney Histopathology After COVID-19 and SARS-CoV-2 Vaccination
|
||
Recruiting |
NCT05563753 -
Early Antibiotic Therapy and Vaccinations in Preterm Infants
|
||
Completed |
NCT05160766 -
Assessing Immune Response of Different COVID-19 Vaccines in Older Adults
|
Phase 2 | |
Not yet recruiting |
NCT06098703 -
CARD for Community Pharmacy Vaccinations
|
N/A | |
Recruiting |
NCT06023056 -
Hepatitis B Vaccination After Neonatal Surgery
|
||
Withdrawn |
NCT05672654 -
Evaluation of Post-SARS-CoV-2 Vaccinal Response in Immunocompromised Patients
|
N/A | |
Not yet recruiting |
NCT06373510 -
Longitudinal Evaluation of Antibody Kinetics of Vaccinated Patients With Non-mandatory Vaccine Following Administration of a Non-public Marketed Vaccine in the General Population, Real-life Study
|
N/A | |
Completed |
NCT04934215 -
Evaluation of Post-vaccination Anti-SARS-CoV-2 Serological Response in Health Care Workers With a History of COVID-19.
|
||
Recruiting |
NCT06294262 -
Safety, Tolerability, Immunogenicity and Immunological Mechanisms of TETRALITE, a Novel Seasonal Influenza Vaccine
|
Phase 1/Phase 2 |