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Uveal Neoplasms clinical trials

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NCT ID: NCT05170334 Recruiting - Clinical trials for Metastatic Uveal Melanoma

Binimetinib Plus Belinostat for Subjects With Metastatic Uveal Melanoma

Start date: December 15, 2021
Phase: Phase 2
Study type: Interventional

This research study is investigating Binimetinib and Belinostat in participants with metastatic uveal melanoma. The research study will test the study drugs to see if the combination of binimetinib and belinostat can make tumors shrink or stop growing.

NCT ID: NCT05077280 Recruiting - Uveal Melanoma Clinical Trials

A Study of Concurrent Stereotactic Body Radiotherapy With Opdualag in Metastatic Uveal Melanoma

Start date: September 20, 2021
Phase: Phase 2
Study type: Interventional

This is a phase 2 trial of concurrent stereotactic radiation therapy (SBRT) with immunotherapy with relatlimab and nivolumab for up to two years. SBRT will be given in three doses of 15Gy each to 1-5 separate metastases. Opdualag (nivolumab 480mg and relatlimab 160mg) will be given every 4 weeks for two years

NCT ID: NCT05047276 Not yet recruiting - Clinical trials for Uveal Melanoma, Metastatic

Phase I/II Study of AloCelyvir in Patients With Metastatic Uveal Melanoma

PULSE-UM
Start date: October 1, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

This is a non-randomized, single arm, single center, phase I/II study of AloCelyvir in subjects with mUM to the liver, the main site for M1 in this disease. This study is divided into 3 phases: Screening, Treatment, and Follow-up. After informed consent is obtained, subjects will enter in the Screening phase to assess eligibility criteria and perform a mandatory tumor biopsy. Upon meeting criteria, eligible subjects will be entered into the Treatment phase. Patients will receive AloCelyvir in weekly intravenous infusions at doses of 0.5x106 cells/kg for 8 weeks. After 4 first treatment doses a new tumor biopsy will be mandatory. Treatment will be maintained for 2 months (8 weeks) but can be stopped earlier if disease progression, unacceptable toxicity, or patient withdrawal. Subjects that are no longer receiving AloCelyvir will enter the Follow-up phase. Subjects that are no longer receiving AloCelyvir because of unacceptable toxicity or due to investigator judgment will undergo radiological evaluations of the tumor every 8 weeks during the first 12 months (48 weeks), and then every 12 weeks until the progression of disease (progression follow-up). Subjects that are no longer receiving Alocelyvir because of progression will enter the long term OS follow-up until their death or until the end of the study, whatever happens before. Subjects who have switched to an alternative treatment without disease progression will receive a formal follow-up with images tests until progression, and after progression long term follow up to record the date of death.

NCT ID: NCT05004025 Recruiting - Uveal Melanoma Clinical Trials

Single Arm Trial of Tumor-Treating Fields in Combination With Nivolumab and Ipilimumab in Metastatic Uveal Melanoma

Start date: February 28, 2022
Phase: Phase 1
Study type: Interventional

Tumor Treating Fields targeted to liver metastases may improve outcomes for patients with metastatic uveal melanoma treated with immune checkpoint inhibitors.

NCT ID: NCT04960891 Available - Uveal Melanoma Clinical Trials

A Cohort IND Expanded Access Program for Supporting Patient Access to Tebentafusp

Non Applicable
Start date: n/a
Phase:
Study type: Expanded Access

This Expanded Access Program aims to: 1. Provide access to tebentafusp for mUM patients. 2. Provide access to tebentafusp for patients, who were on the control arm of the randomized controlled Phase II trial (IMCgp100-202) and were unable to crossover during the specified window. 3. Ensure that patients, who are benefiting from tebentafusp treatment while participating in an ongoing Immunocore sponsored clinical study (e.g., IMCgp100-102 or IMCgp100-201), may continue tebentafusp treatment on this Programme once the ongoing trial has met all of its key primary and secondary objectives.

NCT ID: NCT04935229 Active, not recruiting - Clinical trials for Metastatic Uveal Melanoma in the Liver

Intrahepatic Delivery of SD-101 by Pressure-Enabled Regional Immuno-oncology (PERIO), With Checkpoint Blockade in Adults With Metastatic Uveal Melanoma

Start date: August 2, 2021
Phase: Phase 1
Study type: Interventional

This study is an open-label, phase 1/1b study of the pressure-enabled hepatic artery infusion of SD-101, a TLR 9 agonist, alone or in combination with intravenous checkpoint blockade in adults with metastatic uveal melanoma.

NCT ID: NCT04879017 Terminated - Clinical trials for Metastatic Uveal Melanoma

FHD-286 in Subjects With Metastatic Uveal Melanoma

Start date: May 11, 2021
Phase: Phase 1
Study type: Interventional

This Phase 1, multicenter, open-label, dose escalation and expansion study is designed to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary clinical activity of FHD-286 oral monotherapy in subjects with metastatic Uveal Melanoma (UM).

NCT ID: NCT04728633 Recruiting - Clinical trials for Metastatic Uveal Melanoma

Transarterial Chemoembolization for the Treatment of Uveal Melanoma With Liver Metastases

Start date: September 27, 2021
Phase: Phase 2
Study type: Interventional

This phase II trial studies the effect of transarterial chemoembolization in treating patients with uveal melanoma that has spread to the liver (liver metastases). Transarterial chemoembolization involves the injection of a blocking agent (gelatin sponge, ethiodized oil) and a chemotherapy agent (carmustine) directly into the artery in the liver to treat liver cancers. Chemotherapy drugs, such as carmustine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. transarterial chemoembolization with carmustine in combination with ethiodized oil and gelatin sponge may help cause the tumors in the liver to shrink or disappear.

NCT ID: NCT04728113 Recruiting - Uveal Melanoma Clinical Trials

Early Integration of Supportive Care for Metastatic Uveal Melanoma Patients (EarlyTogether)

Start date: July 16, 2020
Phase: N/A
Study type: Interventional

The study main objective is to assess whether the early introduction of supportive care demonstrates a benefit on patients' psychological care needs at 6 months (M6), versus oncological standard of care in patients with metastatic UM. Supportive care in patients with metastatic Uveal Melanoma (UM)

NCT ID: NCT04720417 Active, not recruiting - Clinical trials for Metastatic Uveal Melanoma

Defactinib and VS-6766 for the Treatment of Patients With Metastatic Uveal Melanoma

Start date: January 26, 2021
Phase: Phase 2
Study type: Interventional

This phase II trial studies the effect of combining defactinib and VS-6766 in treating patients with uveal melanoma that has spread to other places in the body (metastatic). The way cells communicate with one another (different cell signaling pathways) are overactive in uveal melanoma tumor cells. Giving defactinib together with VS-6766 may block pathways that are important for the growth of uveal melanoma cells, and may result in shrinkage or stabilization of the cancer and prolonged time to disease progression and survival.