Evaluating Serum Sestrin in Leiomyoma Patients

Status Completed

Clinical Trial Summary

Leiomyomas are the most common benign neoplasms of women's reproductive system affecting 20-30% of women within the reproductive ages. Sestrins are serum proteins which are highly expressed under circumstances of DNA damage, hypoxia and oxditive stress and play an important role in autophagia. The aim of this study is to evaluate the relationship of serum sestrin proteins with development of leiomyomas.

Clinical Trial Description

Leiomyomas are the benign neoplasms of uterus and the role of genetics, estrogen levels and obesity has already been shown in their development. Higher levels of serum sestrin proteins have already been associated with DNA damage, hypoxia and oxidative stress and sestrin plays an important role in autophagia. In order to evaluate the role of serum sestrin in the development of leiomyomas 30 patients between 18-45 years of age who were diagnosed with uterine leiomyomas with transvaginal ultrasonography will be included in the study group. Their serum sestrin levels will be determined and compared with that of 30 healthy subjects recruited during the same study period at the same clinic. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04819633
Study type	Observational
Source	Sisli Hamidiye Etfal Training and Research Hospital
Contact
Status	Completed
Phase
Start date	January 1, 2021
Completion date	April 1, 2021

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04519593` - ABSOLUTELY: A Temporary Uterine Blood Supply Occlusion for Laparoscopic Myomectomy in Patients With UTErine LeiomYoma	N/A
Not yet recruiting	`NCT03219385` - Directed Ablation of Uterine Fibroids Using a Noninvasive Approach	N/A
Completed	`NCT01338831` - Phase I Study of LFA102 in Patients With Prolactin Receptor-positive Castration-resistant Prostate Cancer or Prolactin Receptor-positive Metastatic Breast Cancer	Phase 1
Completed	`NCT01468402` - Predictive Factors of Pelvic Magnetic Resonance in the Response of Arterial Embolization of Uterine Leiomyoma	N/A
Completed	`NCT03847077` - Trial of a Patient Education Tool For Leiomyoma	N/A
Completed	`NCT00365989` - MR Guided Focused Ultrasound Treatment of Uterine Fibroids With Enhanced Sonication	Phase 3
Completed	`NCT03751124` - Study of Relugolix With Estradiol and Norethindrone Acetate in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids	Phase 3
Recruiting	`NCT02495311` - The Association Between Adenomyosis/Uterine Myoma and Lower Urinary Tract Symptoms
Completed	`NCT00332033` - Development of a Non-Invasive Treatment for Uterine Leiomyoma (Fibroids)	Phase 2
Completed	`NCT04874246` - Comparison of Concentration of Vasopressin During Robot-assisted Laparoscopic Myomectomy	N/A
Not yet recruiting	`NCT04282863` - Comparison Between Robotic (RM) and Laparoscopic Myomectomy (LM)	N/A
Recruiting	`NCT06115408` - Evaluation of Using Dienogest and N-Acetyl Cysteine on the Volume of Uterine Leiomyoma	Phase 2/Phase 3
Completed	`NCT02059954` - Vaginal vs. Laparoscopic Hysterectomy	N/A
Completed	`NCT02049242` - Uterine Tourniquet at Open Myomectomy	N/A
Terminated	`NCT01738724` - Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared to Desogestrel and Goserelin	Phase 4
Terminated	`NCT01280045` - Influence of Aromatase Inhibitors and GnRH Analogs to Treat Uterine Leiomyoma by Vaginal Hysterectomy	N/A
Withdrawn	`NCT02736435` - Treatment of Uterine Fibroids With Magnetic Resonance Guided High Intensity Focused Ultrasound	Phase 3
Completed	`NCT00341848` - Postpartum Uterine Regression
Completed	`NCT01715597` - Study on the Effect of Intravenous Ascorbic Acid on Intraoperative Blood Loss in Women With Uterine Myoma	Phase 3
Completed	`NCT03328260` - High Intensity Focused Ultrasound in Uterine Myoma	N/A