Uterine Fibroids Clinical Trial
Official title:
Magnetic Resonance Elastography (MRE) of Uterine Fibroids
The purpose of this study is to gain additional information regarding use of Magnetic
Resonance Elastography (MRE) for uterine fibroid characterization. In this study, the
investigators will use a new noninvasive technology, MRE, to further characterize the
elastic properties of the uterine fibroids. To date, very little is known concerning how the
tissue composition of the uterine fibroid may affect its treatment with Magnetic Resonance
Guided Focused Ultrasound (MRgFUS).
In this study, the investigators will use a new noninvasive technology, magnetic resonance
elastography (MRE), to further characterize the elastic properties of the uterine fibroids.
This information will be gathered during routine magnetic resonance imaging for symptomatic
uterine fibroids. It is known that some fibroids with increased T2-signal on Magnetic
Resonance Imaging(MRI) can be more difficult to treat.
This information will be gathered during routine magnetic resonance imaging for symptomatic
uterine fibroids.
This is a single-site, non-randomized pilot study to determine whether Magnetic Resonance
Elastography (MRE) can be optimized for clinical use as part of the patients routine
clinical imaging and to correlate with MR signal characteristics of the uterine fibroid.
MRE is performed at the end of the examination after the standard Magnetic Resonance Imaging
protocol.
Aims:
Specific Aim 1: To acquire magnetic resonance elastography images on women who have a
clinically ordered pelvic magnetic resonance imaging (MRI) for uterine fibroids.
Specific Aim 2: To examine the correlation between MRE stiffness values and MR T2 signal
characteristics for uterine fibroids. For a subset of patients going on to surgery
correlation with pathology can also be performed.
This study will seek to determine whether MRE can be performed in the pelvis on a routine
clinical basis as well as correlating the MRE findings with magnetic resonance signal
characteristics. There are no additional risks to the patient and no additional cost to the
MRI exam.
;
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01441635 -
Safety and Efficacy of Elagolix in Pre-Menopausal Women With Heavy Uterine Bleeding and Uterine Fibroids
|
Phase 2 | |
| Completed |
NCT00958334 -
Extension Study of Proellex in Women Who Have Previously Completed Study ZPU 003
|
Phase 2 | |
| Withdrawn |
NCT04567589 -
A Study to Evaluate Awareness and Knowledge of the Fibristal Additional Risk Minimization Measures Among Healthcare Professionals in Canada
|
||
| Recruiting |
NCT05078307 -
Evaluation of a Hysteroscopic Method With Vaporization in the Hysteroscopic Treatment of Submucosal Uterine Fibroids
|
N/A | |
| Recruiting |
NCT02283502 -
Clinical Test of the MRgHIFU System on Uterine Fibroids
|
Phase 1 | |
| Completed |
NCT01631903 -
Extension of Study ZPV-200
|
Phase 2 | |
| Completed |
NCT01739621 -
Safety, Pharmacokinetics and Efficacy of Proellex® (Telapristone Acetate) Administered Vaginally in the Treatment of Premenopausal Women With Uterine Fibroids Who Have Completed ZPV-200
|
Phase 2 | |
| Withdrawn |
NCT00768742 -
Safety and Effectiveness Study of RF Ablation of Uterine Fibroids to Reduce Menstrual Bleeding: the Fibroid Ablation Study
|
N/A | |
| Completed |
NCT00152256 -
A Study to Evaluate of the Safety and Effectiveness of Asoprisnil in Treating Women With Uterine Fibroids
|
Phase 3 | |
| Not yet recruiting |
NCT03586947 -
Association Between Vitamin D and the Risk of Uterine Fibroids
|
N/A | |
| Completed |
NCT02925494 -
An Extension Study to Evaluate the Efficacy and Safety of Elagolix in Premenopausal Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids
|
Phase 3 | |
| Not yet recruiting |
NCT06055114 -
Study on Vaginal Microecology and Cervical Local Immune Function in Patients With Uterine Fibroids of Childbearing Age
|
||
| Terminated |
NCT05026502 -
A Study to Assess Patient-Reported Quality of Life and Effectiveness on Control of Bleeding in Adult Participants With Heavy Menstrual Bleeding Due to Uterine Fibroids Taking Oral Oriahnn Capsules
|
||
| Withdrawn |
NCT04567095 -
A Study to Evaluate Awareness and Knowledge of the Fibristal Additional Risk Minimization Measures Among Patients in Canada
|
||
| Withdrawn |
NCT03699176 -
Assessment of Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids
|
Phase 3 | |
| Not yet recruiting |
NCT02884960 -
Safety and Efficacy of Embozene Microspheres for Uterine Fibroid Embolization
|
N/A | |
| Completed |
NCT02472184 -
Optimal Order of Concurrent Office Hysteroscopy and Endometrial Biopsy
|
N/A | |
| Terminated |
NCT01555073 -
Preemptive Analgesia Following Uterine Artery Embolization
|
Phase 4 | |
| Completed |
NCT01452659 -
Efficacy and Safety of TAK-385 in the Treatment of Uterine Fibroids
|
Phase 2 | |
| Terminated |
NCT00785356 -
Safety and Efficacy of Proellex in Pre-Menopausal Anemic Women With Symptomatic Uterine Fibroids
|
Phase 3 |