Uterine Fibroids Clinical Trial
Official title:
The Effect of Preoperative Treatment With Mifepristone on Uterine Fibroids and Breast Tissue
Uterine fibroids are a benign but common condition among women in reproductive age. It is
one of the most common reasons for hysterectomy since it often causes bleeding problems
sometimes leading to anemia. Several alternative treatment regimens have been investigated
that could replace surgery. The antiprogesterone, mifepristone, is one of the most promising
drugs that have been tested. In addition to the inhibiting effect on the growth of uterine
fibroids antiprogestins have been proposed to have an antiproliferative effect on breast
tissue.
The purpose of the present study is to evaluate the effect of mifepristone on the volume of
uterine fibroids. The study will also address the effect of mifepristone on the breast
tissue
Other purposes of this study include:
- To develop a new non-surgical method for treatment of uterine fibroids
- To study the effect of mifepristone on the size of uterine fibroids
- To evaluate factors regulating fibroid growth by comparison with untreated fibroids and
normal myometrium
- To study the effect of mifepristone on the amount of blood loss and pelvic pain in
patients with fibroids
- To study the effect of mifepristone on proliferation of breast tissue
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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