Clinical Trials Logo

Uterine Fibroids clinical trials

View clinical trials related to Uterine Fibroids.

Filter by:

NCT ID: NCT02301897 Completed - Uterine Fibroids Clinical Trials

A Multi-Center, Parallel Design, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of 6 and 12 mg Proellex® (Telapristone Acetate) Administered Orally in the Treatment of Premenopausal Women With Confirmed Symptomatic Uterine Fibroids

Start date: March 16, 2015
Phase: Phase 2
Study type: Interventional

The primary objective of this study is to determine the safety and efficacy of two oral doses of Proellex administered for up to 2 courses of treatment (18 weeks each), each separated by an Off-Drug Interval (ODI), to premenopausal women with symptomatic uterine fibroids.

NCT ID: NCT02192606 Completed - Pelvic Pain Clinical Trials

Does 3D Laparoscopy Improve Vaginal Cuff Suture Time?

3DRCT
Start date: November 2013
Phase: N/A
Study type: Interventional

The objective aim is to evaluate whether the use of 3D laparoscopy facilitates the vaginal cuff closure of the vaginal cuff during a total laparoscopic hysterectomy among novice laparoscopists (PGY 2-4, Fellow). This is a randomized single blinded controlled trial comparing the difference in 2D vs. 3D in regards to vaginal cuff closure time stratified by residents and fellows. Patients will undergo a total laparoscopic hysterectomy and will be randomized to either 2D versus 3D.

NCT ID: NCT02086370 Completed - Uterine Fibroids Clinical Trials

Prophylactic Salpingectomy for the Prevention of the Ovarian Cancer: Comparison Between Surgical Techniques

Rad_PBS
Start date: March 2014
Phase: N/A
Study type: Interventional

The aim of this RCT of study is to compare the outcomes of the standard salpingectomy (removal of the fallopian tube) with the radical removal of the tube and the mesosalpinx in terms of ovarian reserve.

NCT ID: NCT02086279 Completed - Endometriosis Clinical Trials

AMH Levels Change During Treatment With GnRh Agonist

Start date: March 2014
Phase: N/A
Study type: Interventional

To evaluate the variation of AMH levels in women undergoing treatment with GnRHa, and to assess whether this variation correlates with changes in the antral and pre-antral follicle ultrasonographic count (AFC).

NCT ID: NCT02059954 Completed - Uterine Fibroids Clinical Trials

Vaginal vs. Laparoscopic Hysterectomy

Start date: January 2014
Phase: N/A
Study type: Interventional

Hysterectomy for benign indication is one of the most common surgical procedures in women. Numerous reviews and guidelines recommend the vaginal approach for benign hysterectomy, but the proportion of laparoscopic (and robotic) hysterectomies is increasing. This study will compare a range of clinical and subjective outcomes of vaginal vs. total laparoscopic hysterectomy. Outcomes include operating time, postoperative recovery, return to work as well as cosmesis, quality of life and sexual health.

NCT ID: NCT01992718 Completed - Uterine Fibroids Clinical Trials

What Are we Missing? Diagnosing Uterine Adenomyosis Using Ultrasound Elastography

Start date: November 2013
Phase: Early Phase 1
Study type: Interventional

To improve the clinical care of women with pelvic pain and abnormal uterine bleeding due to benign uterine conditions including leiomyomas (uterine fibroids) and adenomyosis by evaluating the accuracy of radiology diagnostic exams (MRI(magnetic resonance imaging), ultrasound and ultrasound with elastography).

NCT ID: NCT01936493 Completed - Uterine Fibroids Clinical Trials

Biologic Predictors of Leiomyoma Treatment Outcomes

Start date: August 2009
Phase: N/A
Study type: Observational

The purpose of this study is to search for the hereditary (genetic) causes of uterine fibroids. Some women with uterine fibroids may have one or more genes that make them more likely to develop uterine fibroids. We are trying to identify these genes to better understand how and why uterine fibroids develop and to design better treatment options for women with uterine fibroids. This information may also help us to understand and treat other problems that may be caused by these genes.

NCT ID: NCT01865929 Completed - Uterine Fibroids Clinical Trials

Minimally Invasive Benign Hysterectomy

Start date: January 2010
Phase: N/A
Study type: Interventional

A randomised controlled trial comparing hysterectomy by minimally invasive surgical methods; robotic hysterectomy versus vaginal hysterectomy or traditional laparoscopic hysterectomy; outcome and cost analyses.

NCT ID: NCT01852734 Completed - Uterine Fibroids Clinical Trials

Uterine Fibroid Embolization- Long Term Follow up and Technical Perspectives

Start date: November 2013
Phase: N/A
Study type: Interventional

The purpose of this prospective non-randomised study is to examine whether two different microspheres (Bead-Block and Embosphere) are equally effective in the treatment of the uterine fibroid controlled with contrast-enhanced MR examination. Quantitative MR imaging, including dominant fibroid T1, T2 and contrast enhancement characteristics before intervention and 3 months after interventions will be analysed as a potential predictor of volumetric response after embolization. Another purpose is to determine long-term follow-up in all patient treated in a period from 2001-2011 in OUH analysed retrospectively.

NCT ID: NCT01840124 Completed - Uterine Fibroids Clinical Trials

Uterine Leiomyoma Treatment With Radiofrequency Ablation

ULTRA
Start date: July 2013
Phase: N/A
Study type: Interventional

The ULTRA study is a single-arm trial of 100 premenopausal women with symptomatic uterine fibroids who undergo treatment with the Acessa device. The Acessa device is a new FDA approved minimally invasive treatment for uterine fibroids that uses radiofrequency energy to destroy fibroid tissue. The fibroids then shrink and symptoms are significantly improved. The radiofrequency energy is delivered to the fibroids during an outpatient surgical procedure. There is minimal blood loss and pain and women return to the usual activities 5-9 days after the Acessa procedure. The investigators will evaluate changes in fibroid-related symptoms from before the Acessa treatment to 3, 6, 12, 18, 24, 30, and 36 months after Acessa treatment. The investigators will also assess operative outcomes including procedure duration, complications, blood loss, post-operative pain, and the time to return to usual activities. The investigators will determine long-term efficacy of Acessa by evaluating the rate of re-treatment for symptomatic fibroids after the Acessa procedure. Study participants will be recruited at 5 sites within the UC Fibroid Network: UC Davis, UC Irvine, UC Los Angeles, UC San Diego, and UC San Francisco. UC San Francisco will serve as the Coordinating Center for the trial with oversight of all scientific and administrative aspects of the study. All study data will be stored securely in a HIPAA compliant, secure database monitored by the UC San Francisco Coordinating Center. A data safety and monitoring board will oversee participant safety and protection.