Uterine Cervical Neoplasms Clinical Trial
Official title:
`F-18 Fluorothymidine ([18F]FLT) PET Imaging for Early Evaluation of Response to Chemoradiation Therapy in Patients With Cervical Cancer
Our primary hypothesis is that [18F]FLT PET can identify active bone marrow in addition to
metabolically active tumor.
This trial will use FLT-PET imaging to define areas of active bone marrow in the pelvis. The
radiation plan is then designed to spare that area, in hopes of keeping the bone marrow
active during therapy. Bone marrow and tumor activity will be monitored using a sequence of
FLT PET scans during the course of chemotherapy and radiation therapy.
Subjects will undergo a total of up to 5 FLT PET scans.
Subjects are randomized between two groups to reduce radiation exposure from the FLT PET
scans. If bone marrow activity is not identified in one scan, further scans are cancelled
until the 1-month follow up scan. This is not a randomization to compare therapeutic efficacy
between two study arms. Data will be pooled for analysis as pre-specified in the study's
statistical plan.
Group 1 has FLT PET scans pretreatment, after 5 radiation treatments, after 10 radiation
treatments, after 15 radiation treatments, and then 1 month after completing radiation
therapy.
Group 2 has FLT PET scans pretreatment, after 5 radiation treatments, after 10 radiation
treatments, after 20 radiation treatments, and then 1 month after completing radiation
therapy.
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