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Clinical Trial Summary

Isolated urticaria in the emergency department is widely treated by physicians with histamine blocking agents such as diphenhydramine, cetirizine, and cimetidine. Doxepin is a tricyclic antidepressant that has been shown to have much higher concentrations of histamine blocking activity and therefore may be useful in treating urticaria. The purpose of this study is to compare the effectiveness of using doxepin verses a traditional medication, diphenhydramine (Benadryl), in the treatment of isolated urticaria in the emergency department.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT05115136
Study type Interventional
Source State University of New York - Upstate Medical University
Contact David Andonian, MD
Phone 315-464-4363
Email [email protected]
Status Recruiting
Phase Phase 3
Start date November 8, 2021
Completion date July 1, 2023

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