Urothelial Carcinoma Bladder Clinical Trial
Official title:
Assessment of Decision Tool to Select Women for Gynecologic Sparing Radical Cystectomy
Currently, the standard of care for female patients undergoing radical cystectomy includes the removal of the bladder, pelvic lymph nodes, anterior vagina, uterus, fallopian tubes and ovaries. Removal of female ancillary organs, both in pre and post-menopausal stages is associated with reduction in various quality of life metrics, including sexual health, cognitive decline and depression. Furthermore, removal of ovaries has been associated with increased cardiovascular events, metabolic acidosis, osteoporosis and bone fractures. In premenopausal women, the removal of the ovaries is associated with increased all-cause mortality. From an oncologic standpoint, multi institutional retrospective reviews have demonstrated certain pre-operative radiographic and cystoscopic risk factors that are associated with bladder cancer involvement of female reproductive organs. The absence of these unfavorable risk factors may provide an opportunity to spare women from undergoing unnecessary reproductive organ removal during RC. In doing so, this may eliminate the associated sequelae of removing these additional organs while also providing acceptable oncologic care. The investigators thus propose a decision tool to stratify women undergoing radical cystectomy as favorable and unfavorable for reproductive organ sparing radical cystectomy. This decision tool classification will be used to decide which patients will undergo reproductive organ sparing radical cystectomy versus radical cystectomy in this study.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Terminated |
NCT03606174 -
A Phase 2 Study of Sitravatinib in Combination With PD-(L)1 Checkpoint Inhibitor Regimens in Patients With Advanced or Metastatic Urothelial Carcinoma
|
Phase 2 | |
Recruiting |
NCT05839119 -
Targeting Androgen Signaling in Urothelial Cell Carcinoma - Neoadjuvant
|
Phase 1 | |
Completed |
NCT03558503 -
A Phase 2b Study of UGN-102 for Low Grade Intermediate Risk Non-Muscle-Invasive Bladder Cancer
|
Phase 2 | |
Completed |
NCT05136898 -
Feasibility of Home Instillation of UGN-102 for Treatment of Low-Grade (LG) Non-Muscle-Invasive Bladder Cancer (NMIBC)
|
Phase 3 | |
Withdrawn |
NCT06090318 -
Milademetan in Combination With Atezolizumab in Patients With Advanced Solid Tumors With CDKN2A Loss
|
Phase 1/Phase 2 | |
Recruiting |
NCT03185468 -
Intervention of Bladder Cancer by CAR-T
|
Phase 1/Phase 2 | |
Active, not recruiting |
NCT05243550 -
A Phase 3 Single-Arm Study of UGN-102 for Treatment of Low Grade Intermediate Risk Non-Muscle-Invasive Bladder Cancer
|
Phase 3 | |
Recruiting |
NCT05312671 -
Atezolizumab Plus Etoposide and Platinum in Small Cell Bladder Cancer
|
Phase 2 | |
Recruiting |
NCT02951325 -
Bladder Cancer Adjuvant Radiotherapy Trial
|
N/A | |
Recruiting |
NCT05401279 -
Bladder Sparing Treatment of Tislelizumab, Gemcitabine and Cisplatin for Patients With PD-L1 Positive Muscle Invasive Bladder Cancer
|
Phase 2 | |
Recruiting |
NCT05375903 -
A Phase 1 Dose-escalation Study of UGN-301 in Patients With Recurrent Non-muscle Invasive Bladder Cancer (NMIBC)
|
Phase 1 | |
Active, not recruiting |
NCT04386746 -
Intravesical Gemcitabine and Docetaxel for BCG naïve Non-muscle Invasive Bladder Cancer
|
Phase 2 | |
Not yet recruiting |
NCT05656235 -
Renal Retention in High Grade Upper Tract Urothelial Cancer
|
Phase 2 | |
Not yet recruiting |
NCT06331299 -
A Phase 3 Study of UGN-103 for Treatment of Patients With Low-grade Intermediate-risk Non-muscle Invasive Bladder Cancer
|
Phase 3 | |
Not yet recruiting |
NCT05037279 -
Evaluating Safety and Efficacy of Verity-BCG in BCG-naïve Patients With Intermediate and High-risk Non-muscle Invasive Bladder (NMIBC)
|
Phase 3 | |
Terminated |
NCT04688931 -
A Phase 3 Study of UGN-102 for Low-Grade Intermediate-Risk Non-Muscle Invasive Bladder Cancer
|
Phase 3 | |
Recruiting |
NCT05241340 -
Neoadjuvant Sasanlimab With Radiation as an in Situ Vaccine for Cisplatin-ineligible Muscle Invasive Bladder Cancer
|
Phase 2 | |
Recruiting |
NCT05077709 -
IO102-IO103 in Combination With Pembrolizumab as First-line Treatment for Patients With Metastatic NSCLC, SCCHN, or mUBC
|
Phase 2 | |
Completed |
NCT04200963 -
A Phase 1a/b Study of IK-175 as a Single Agent and in Combination With Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumors and Urothelial Carcinoma
|
Phase 1 | |
Recruiting |
NCT04770974 -
Urothelial Cancer Tumor Bio-markers and Physical-spectroscopic Characteristic
|