Short Therapy for Febrile UTI in Childhood

Status Completed

Clinical Trial Summary

Febrile urinary tract infections (UTIs) are common in children, but there is no consensus concerning the duration of the antibiotic treatment. Current recommendations include the use of an oral antibiotic, chosen between amoxicillin and clavulanic acid or a third-generation cephalosporin (ceftibuten), for a minimum of seven to a maximum of 14 days. In an antibiotic overuse-sparing model, proper evaluation of a shorter therapy in the treatment of febrile UTI in childhood is lacking. The objective of this randomized controlled trial is to assess the non inferiority of a five days oral course of amoxicillin and clavulanic acid vs the standard 10-day regimen in the treatment of febrile UTIs in children. The trial results might provide evidence of the non-inferiority of a short duration of the antibiotic course for the treatment of febrile UTI in childhood, contributing to a reduction in the over-use of antibiotics and consequently limiting the emergence of antibiotic resistance.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04400110
Study type	Interventional
Source	IRCCS Burlo Garofolo
Contact
Status	Completed
Phase	Phase 4
Start date	June 8, 2020
Completion date	December 31, 2022

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04495699` - Asymptomatic Renal Calculi in Recurrent Urinary Tract Infections
Terminated	`NCT05254808` - EXtended Use of FOsfomycin for the Treatment of CYstitis in Primary Care	Phase 3
Completed	`NCT03680612` - Cefepime/AAI101 Phase 2 Study in Hospitalized Adults With cUTI	Phase 2
Completed	`NCT03282006` - Treating Pyelonephritis an Urosepsis With Pivmecillinam	Phase 4
Completed	`NCT03526484` - The Utility of Urinalysis Prior to In-Office Procedures	N/A
Completed	`NCT05397782` - Effects of Flourish on Recurrent Urinary Tract Infection	N/A
Completed	`NCT05018546` - Safety and Efficacy of Different Irrigation System in Retrograde Intrarenal Surgery	N/A
Completed	`NCT03687255` - Safety and Efficacy Study of Cefepime-AAI101 in the Treatment of Complicated Urinary Tract Infections	Phase 3
Recruiting	`NCT05227937` - Single Dose Amikacin for Uncomplicated Cystitis in the ED: A Feasibility Study
Completed	`NCT02864420` - Hospitalization at Home: The Acute Care Home Hospital Program for Adults	N/A
Completed	`NCT03131609` - Avoiding Bacterial Contamination of Clean Catch Urine Cultures in Ambulatory Patients in the Emergency Department
Completed	`NCT01911143` - A Retrospective, Blinded Validation of a Host-response Based Diagnostics	N/A
Completed	`NCT01333254` - A Trial of Different Methods for Bladder Drainage in Hip Surgery Patients	N/A
Terminated	`NCT00594594` - Adjuntive Probiotic Therapy in Treating Urinary Tract Infections in Spinal Cord Injury	Phase 1
Completed	`NCT00216853` - A Study of Vaginal MicroFlora and Immune Profiles of Patients With Recurrent Urinary Tract Infection	N/A
Completed	`NCT00787085` - The Significance of Funguria in Hospitalized Patients	N/A
Completed	`NCT05719753` - The Effectiveness of a Bacteriophobic Coating on Urinary Catheters	N/A
Recruiting	`NCT05415865` - The Effect of Local Anesthetic Solution in the Bladder Prior to Botox Injections in the Bladder	Phase 3
Not yet recruiting	`NCT05880329` - DIagnoSing Care hOme UTI Study
Recruiting	`NCT04615065` - Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine