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Alternative Prophylaxis in Female Recurrent Urinary Tract Infections — AlP-FrUiT  

Urinary Tract Infections Clinical Trial

Official title:
Non-antimicrobial Alternative in Prophylaxis of Recurrent Urinary Tract Infections: a Prospective, Randomised-controlled, Double-blinded, Multicentre Study

Clinical Trial Summary

Urological pathogens are effected by rising antimicrobial resistance rates due to the frequent use of antimicrobials for treatment and prophylaxis. Intravesical instillation with hyaluronic acid (HA) and chondroitin sulphate (CS) obtained positive outcomes in the treatment of overactive bladder, radiation cystitis and interstitial cystitis by replenishment of the glycosaminoglycan layer of the bladder. This study is to investigate whether intravesical instillation with HA-CS in patients with recurrent urinary tract infections (rUTI) is superior to a placebo instillation in terms of reduction of rate of symptomatic urinary tract infections (UTIs) (based on clinical diagnosis) needing treatment with antimicrobials within 12 months after randomisation.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04095572
Study type Interventional
Source University Hospital, Basel, Switzerland
Contact Kathrin Bausch, Dr. med
Phone +41 61 265 72 80
Email kathrin.bausch@usb.ch
Status Recruiting
Phase Phase 4
Start date October 27, 2020
Completion date June 2026
View Details
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