Urinary Tract Disease Clinical Trial
Official title:
Brain Effects of Sacral Neuromodulation in Patients With Refractory Lower Urinary Tract Dysfunction
Sacral neuromodulation (SNM) has become an accepted treatment for patients with refractory
lower urinary tract dysfunction such as urgency frequency syndrome, urgency incontinence,
non-obstructive chronic urinary retention and chronic pelvic pain syndrome. Modulation of
central afferent activity is considered critical to this therapeutic effect but the neural
mechanisms are poorly understood.
We hypothesize that SNM has a significant effect on brain activity detectable by positron
emission tomography (PET).
n/a
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science
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