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Clinical Trial Summary

Treatment of patients with urinary incontinence after prostatectomy using injection of autologous adipose-derived mesenchymal stem cells mixed with collagen gel


Clinical Trial Description

During the implementation of the project, it is planned to develop a method for the treatment of men urinary incontinence caused by prostatectomy using injection of autologous adipose-derived mesenchymal stem cells mixed with collagen. The positive outlook for the effectiveness of MSCs is due to the following: - the ability of MSCs to stimulate tissue regeneration - positive results of preclinical studies of the method of treatment of urinary incontinence in animals. In study planing to include 5 patients. MSCs will be isolated from adipose tissue, cultured and then transplanted back to the periurethral area by five point injection in rhabdosphincter and submucosal space of urethra using the cystourethroscope. For injection in submucosal space MSCs (20*10^6 cells) will be mixed with collagen solution (3,5% w|w). Follow up patients monitoring will occur at 1,3,6 and 12 months after injection. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04426643
Study type Interventional
Source Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Contact
Status Completed
Phase Phase 1/Phase 2
Start date August 1, 2020
Completion date March 31, 2021

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