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Urgency Urinary clinical trials

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NCT ID: NCT05463822 Completed - Overactive Bladder Clinical Trials

Transvaginal Botulinum Toxin A Chemodenervation for Overactive Bladder

FETOC
Start date: June 20, 2019
Phase: Early Phase 1
Study type: Interventional

Overactive bladder (OAB) is a highly prevalent disease process that, when refractory to oral medication therapy, can be effectively managed with injection of botulinum toxin A (BTA) into the detrusor muscle of the bladder. However, the traditional procedure requires a cystoscope inserted into the bladder which can be painful and is associated with a risk of urinary tract infection. The purpose of this study is to determine if transvaginal injection of BTA into the detrusor muscle of the bladder wall is feasible to perform, and efficacious for the treatment of refractory overactive bladder.

NCT ID: NCT04090190 Completed - Clinical trials for Urinary Incontinence

Inflammation in Women With Urgency Urinary Incontinence Treated With Anticholinergics

Start date: October 30, 2019
Phase: Phase 4
Study type: Interventional

Urinary incontinence (UI) is a very common condition affecting women of all ages. The objective of this pilot study is to better understand the urinary microbiome and associated inflammatory markers in blood and urine in women with urgency UI. The study will assess how inflammation may affect response to standard of care anticholinergic medication treatment for urgency urinary incontinence.

NCT ID: NCT03672461 Completed - Clinical trials for Urinary Incontinence, Stress

A Group-Based Therapeutic Yoga Intervention for Urinary Incontinence in Ambulatory Older Women

Start date: March 6, 2019
Phase: N/A
Study type: Interventional

The investigators will conduct a randomized controlled trial to evaluate the efficacy of a group-based yoga intervention to decrease the frequency and impact of urinary incontinence in ambulatory middle-aged and older women and explore potential mediators of improvement in outcomes. Women aged 45 years and older who report daily or more frequent stress-, urgency-, or mixed-type incontinence, are not already engaged in formal yoga or muscle stretching/strengthening programs, are willing to temporarily forgo other clinical treatments for incontinence, are able to walk to and use the bathroom without assistance, and meet other eligibility criteria will be recruited from multiple locations surrounding the San Francisco Bay area.