View clinical trials related to Urge Urinary Incontinence.
Filter by:- Urinary Urge Incontinence (UUI) is the involuntary urine loss associated with a strong sensation to void. - UUI usually associated with reduced bladder capacity. - The pathophysiology is unclear. - Pelvic floor muscle dysfunction and detrusor instability have been suggested as possible mechanisms. - Standard treatment includes anticholinergic medication and behavior modification. - The study aims to compare the long term effectiveness of 4 different approaches to the treatment of women with Urge Urinary Incontinence (UUI): 1. Pelvic Floor Rehabilitation (includes muscle training+behavioral intervention+bladder training) 2. Pelvic Floor muscle training alone 3. Bladder Training alone 4. Drug treatment with Tolterodine. - Study variables will include: impairment ratings, quality of life, and cost-effectiveness. - This study addresses three issues: 1. The long term efficacy and cost-effectiveness of the various treatment options. 2. To identify the factors involved in determining the effectiveness of drug or behavioral therapy. 3. The pathophysiology of UUI. By subdividing the rehabilitation group into 3 arms, we hope to shed light on the mechanism of dysfunction. A better response in one group will help localize the problem to pelvic floor muscles or to detrusor instability.
To determine the mechanisms mediating the therapeutic efficacy of pelvic floor muscle exercises and biofeedback for urge urinary incontinence, as well as the characteristics of patients most likely to respond. By identifying the key components of this treatment, we hope to simplify it and make it more easily applicable, more effective, less expensive, and thus more useful for people with urge incontinence in the future.