Comparative Efficacy of Phenylbutyrate (PBA) vs. Benzoate in Urea Cycle Disorders — BPA/Benzoate

Urea Cycle Disorders, Inborn Clinical Trial

Official title:
Comparative Efficacy of Phenylbutyrate vs. Benzoate in Urea Cycle Disorders

Status Completed

Clinical Trial Summary

The investigators will study and compare how effectively sodium phenylbutyrate, sodium benzoate, and a combination of the two, help excrete nitrogen in healthy volunteers. Subject participation will require three, separate, four-day study periods at least one week apart. During one study period (also called a treatment arm), subjects will take sodium phenylbutyrate; during another they will take sodium benzoate; during another they will take a combination of the two medications.

We expect to find that phenylbutyrate is more effective at removing nitrogen than benzoate or a combination of the two.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02111200
Study type	Interventional
Source	Baylor College of Medicine
Contact
Status	Completed
Phase	N/A
Start date	September 2014
Completion date	October 2015

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