Clinical Trials Logo
  1. Home
  2. Urea Cycle Disorder
  3. NCT05330039

Characterization of Intestinal Microbiota in Children With Inborn Errors of Metabolism (IEM) — IEM  

Inborn Errors of Metabolism Clinical Trial

Official title:
Enterobacteria Strain-level Characterization in Children With Inborn Errors of Metabolism (IEM)

Clinical Trial Summary

Study around children with inborn errors of metabolism (IEM) and their healthy siblings. Collection of stool and urine to assess contribution of microbiota to disease severity.

Clinical Trial Description

This study aims to collect biological samples (stool and urine) from children with inborn errors of metabolism, IEM (like UCD (urea cycle disorder), PA (propionic aciduria) and MMA (methylmalonic aciduria) and their healthy siblings. The main focus of the study is to assess the contribution of the intestinal microbiota to disease severity in children that suffer from different forms of IEM and potentially find microbiota targets that could be used in the design of therapeutic/prophylactic agents. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05330039
Study type Observational
Source ETH Zurich
Contact
Status Completed
Phase
Start date November 30, 2021
Completion date February 27, 2024
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT03548779 - North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2 N/A
Completed NCT01049854 - CD34+Selection for Partially Matched Family or Matched Unrelated Adult Donor Transplant Phase 2
Completed NCT00001596 - Oral Pirfenidone for the Pulmonary Fibrosis of Hermansky-Pudlak Syndrome Phase 2
Withdrawn NCT01003912 - Fetal Umbilical Cord Blood (UCB) Transplant for Lysosomal Storage Diseases Phase 1
Completed NCT00744692 - Reduced Intensity Conditioning for Umbilical Cord Blood Transplant in Pediatric Patients With Non-Malignant Disorders Phase 1
Completed NCT00692926 - Unrelated Umbilical Cord Blood Transplantation Augmented With ALDHbr Umbilical Cord Blood Cells Phase 1
Recruiting NCT05818566 - Orphan Drugs for Inherited Metabolic Diseases
Withdrawn NCT03866954 - Trial of Erythrocyte Encapsulated Thymidine Phosphorylase In Mitochondrial Neurogastrointestinal Encephalomyopathy Phase 2
Completed NCT03911089 - A Collection of Case Studies in Infants With UCD to Evaluate Infant Growth and the Safety of a New Medical Food for UCD N/A
Completed NCT03058848 - Evaluation of PKU Start N/A
Suspended NCT04399694 - Identification and Characterization of Novel Non-Coding Variants That Contribute to Genetic Disorders
Terminated NCT00654433 - ALD-101 Adjuvant Therapy of Unrelated Umbilical Cord Blood Transfusion (UCBT) in Patients With Inherited Metabolic Diseases Phase 3
Completed NCT03168399 - Evaluation of PKU Explore N/A
Recruiting NCT00078078 - Clinical and Laboratory Study of Methylmalonic Acidemia
Completed NCT00328159 - Nutritional Therapy of the Deficits of Oxidation Mitochondrial of the Fatty Acids N/A
Completed NCT04309331 - Market Research - Acceptability Trial for a New PKU Amino Acid Based Protein Substitute N/A
Completed NCT04709965 - Evaluating Face-Recognition Technology in Syndrome Diagnosis N/A
Recruiting NCT06360913 - Blood Spot and Urine Metabolomic Screening Applied to Rare Diseases N/A
Completed NCT00309400 - The Early History of Universal Screening for Metabolic Disorders N/A
Completed NCT00004378 - Stem Cell Transplantation (SCT) for Genetic Diseases N/A