Minimum Effective Volume of Lidocaine Costoclavicular Brachial Plexus Block

Upper Extremity Surgery Clinical Trial

Official title:

Minimum Effective Volume of Lidocaine for Ultrasound-Guided Costoclavicular Infraclavicular Brachial Plexus Block

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02932670
• Other study ID #: Montreal General Hospital
• Status: Completed
• Phase: N/A
• First received: October 12, 2016
• Last updated: March 21, 2017
• Start date: October 2016
• Est. completion date: February 2017

Study information

• Verified date: March 2017
• Source: McGill University Health Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to determine the minimum effective volume of lidocaine in 90% of patients (ED90) required for single-injection US-guided costoclavicular infraclavicular.

Description:

The aim of this study is to determine the minimum effective volume of lidocaine in 90% of patients (ED90) required for single-injection US-guided costoclavicular ICB. Determination of the minimum effective volume of LA is important because it prevents the administration of an unnecessarily large (and potentially toxic) dose. Furthermore, when multiple blocks need to be performed at the same time in the same patient, knowledge of the minimum effective volume allows to the operator to preserve efficacy without sacrificing safety for each block.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: February 2017
• Est. primary completion date: January 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• age between 18 and 70 years

• American Society of Anesthesiologists classification 1-3

• body mass index between 20 and 30

Exclusion Criteria:

• adults who are unable to give their own consent

• pre-existing neuropathy (assessed by history and physical examination)

• coagulopathy (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. platelets= 100, International Normalized Ratio= 1.4 or partial prothrombin time = 50)

• renal failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. creatinine= 100)

• hepatic failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. transaminases= 100)

• allergy to local anesthetics

• pregnancy

• prior surgery in the infraclavicular region

• chronic pain syndromes requiring opioid intake at home

Related Conditions & MeSH terms

• Upper Extremity Surgery

Intervention

Other:
• costoclavicular nerve block
ultrasound-guided costoclavicular nerve block

Locations

Country	Name	City	State
Canada	Montreal General Hospital	Montreal	Quebec

Sponsors (1)

Lead Sponsor	Collaborator
McGill University Health Center

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	success rate	minimal composite score of 14 out of 16	0-30 min