UPDRS Clinical Trial
To test the effects of low frequency deep rTMS using the novel H-coil on the motor, affective and cognitive deficits in patients with asymmetric Parkinson's disease (PD) and to establish its safety in this population. The investigators anticipate that reaching deeper brain layers and larger volume of activation with the novel H-coil may induce significantly better therapeutic effects in patients with PD and will pave the way for establishing a novel and effective treatment for this disorder.
Status | Not yet recruiting |
Enrollment | 20 |
Est. completion date | |
Est. primary completion date | July 2010 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 40 Years to 80 Years |
Eligibility |
Inclusion Criteria: - PD patients with asymmetric disease aged 40 years or older, diagnosed as idiopathic PD according to the UK Brain Bank criteria, with Hoehn & Yahr stages II - IV while "off". - Participants on antidepressants should be at least 2 months on stable therapy. Exclusion Criteria: - Patients who have concomitant epilepsy, a history of seizure or heat convulsion or history of epilepsy in first degree relative. - Patients on neuroleptics. - Patients with dementia or any unstable medical disorder. - History or current unstable hypertension. - History of head injury or neurosurgical interventions. - History of any metal in the head (outside the mouth). |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
---|---|
Sheba Medical Center |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Unified Parkinson's Disease Rating Scale (UPDRS ) | 1 year | No | |
Secondary | CGIS,Pegboard test.Tapping test,Up&Go test,AIMS,BDI,MMSE,Word fluencyFAB | 1 year | No | |
Secondary | UPDRS | 3 months | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT06275633 -
Behavioural Profiling of Disease-related Cognitive and Motor Impairment in PD
|
N/A |