Clinical Trials Logo
  1. Home
  2. Unstable Angina
  3. NCT04718025

Evaluation of Safety and Efficacy of Two Ticagrelor-based De-escalation Antiplatelet Strategies in Acute Coronary Syndrome — ELECTRA-SIRIO  

Unstable Angina Clinical Trial

Official title:
Evaluation of Safety and Efficacy of Two Ticagrelor-based De-escalation Antiplatelet Strategies in Acute Coronary Syndrome: the Randomized, Multicenter, Double-blind ELECTRA RCT Study

Clinical Trial Summary

The ELECTRA-SIRIO 2 study is a randomized, multicenter, double-blind, investigator-initiated clinical trial aimed to evaluate safety and efficacy of two ticagrelor-based de-escalation antiplatelet strategies in patients with acute coronary syndrome (ACS). During the hospitalization due to ACS, participants will be randomized in a 1:1:1 ratio into one of three arms: low-dose ticagrelor with aspirin (LDTA), low-dose ticagrelor with placebo (LDTP), and standard-dose ticagrelor with aspirin (SDTA), the latter being the control arm. Up to day 30, all enrolled patients will receive standard-dose ticagrelor (2x90mg) + aspirin (1x100mg). Starting from day 31 LDTA and LDTP patients will receive low-dose ticagrelor (2x60mg) + aspirin (1x100mg), SDTA - continuation of previous treatment. Starting from day 91 LDTP patients will receive low-dose ticagrelor (2x60mg) + placebo, SDTA and LDTA - continuation of previous treatment. The aim of the study is to evaluate the influence of ticagrelor maintenance dose reduction from 2x90mg to 2x60mg with or without continuation of aspirin versus dual antiplatelet therapy with standard dose ticagrelor in reducing clinically relevant bleeding and maintaining anti-ischemic efficacy in ACS patients.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04718025
Study type Interventional
Source Collegium Medicum w Bydgoszczy
Contact Piotr Adamski, MD, PhD
Phone +48 52 585 4023
Email piotr.adamski@cm.umk.pl
Status Recruiting
Phase Phase 3
Start date February 7, 2022
Completion date June 30, 2024
View Details
See also
  Status Clinical Trial Phase
Completed NCT05563701 - Evaluation of the LVivo Image Quality Scoring (IQS)
Completed NCT04097912 - Study to Gather Information to What Extent Patients Follow the Treatment Regimen of Low-dose Aspirin for Primary and Secondary Prevention of Diseases of the Heart and Blood Vessels
Not yet recruiting NCT03610529 - CardioSenseSystem Compared Study Regarding Efficacy and Safety in the Monitoring of ECG N/A
Withdrawn NCT03906812 - A Randomized Trial of Telemetry Compared With Unmonitored Floor Admissions in ED Patients With Low-Risk Chest Pain N/A
Completed NCT01826552 - Comparison of the Angiographic Result of the Orsiro Hybrid Stent With Resolute Integrity Stent Phase 4
Completed NCT01688648 - Comparison Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft N/A
Completed NCT01709669 - The Impact of Gratitude on Biology and Behavior in Persons With Heart Disease N/A
Completed NCT01171404 - Study Evaluating How Patients With Acute Coronary Syndrome Are Managed During 2 Years After Discharge N/A
Completed NCT01167582 - Myocardial Ischemia and Transfusion Pilot Phase 3
Completed NCT01020383 - Comparative Study of ALX-0081 Versus GPIIb/IIIa Inhibitor in High Risk Percutaneous Coronary Intervention (PCI) Patients Phase 2
Completed NCT00449826 - Risk Stratification of Non ST Elevation ACS With Computed Tomographic Angiography (REACT) N/A
Terminated NCT00355992 - The Ischemia Modified Albumin In Diagnosing Ischemic New Events N/A
Completed NCT00263263 - RRISC Study: Reduction of Restenosis In Saphenous Vein Grafts With Cypher Sirolimus-Eluting Stent. Phase 2
Active, not recruiting NCT04929496 - Physiology as Guidance to Evaluate the Direct Impact of Coronary Lesion Treatment: The PREDICT Study N/A
Completed NCT03103620 - Safety and Effectiveness Evaluation of COBRA PzF Coronary Stent System: A Post Marketing Observational Registry
Completed NCT04648306 - Restore EF Observational Study
Not yet recruiting NCT03266289 - Evaluation of Short Term Outcome of Different Bifurcation Stenting Techniques at Assuit University Cath. Lab N/A
Not yet recruiting NCT04403048 - Drug Coated Balloon for Side Branch Treatment vs. Conventional Approach in True Bifurcation Coronary Disease: PRO-DAVID N/A
Recruiting NCT02748603 - Appropriateness of Coronary Angioplasty in PAtients With isCHEmic Heart Disease N/A
Completed NCT01774838 - Vasoactive and Anti-inflammatory Effects of Prasugrel in Acute Coronary Syndrome Phase 3