Clinical Trials Logo

Clinical Trial Summary

The study is to evaluate efficacy and safety of low dose of ticagrelor therapy for Chinese unstable angina patients treated with non-urgent coronary stent implantation, to examine whether lower dose ticagrelor (45 mg twice-daily) is not inferior to standard dose (90 mg twice-daily) for the prevention of major adverse cardiovascular and cerebrovascular events, as well as will reduce the incidence of bleeding during long-term treatment.


Clinical Trial Description

This is a prospective, single center, randomized, parallel-group trial designed to evaluate the efficacy and safety of low dose ticagrelor on a background of aspirin for patients treated with non-urgent coronary stent implantation. 2036 subjects will be enrolled. All patients will receive treatment with aspirin and a P2Y12 inhibitor for 3 months after the index procedure. At 3 months, eligible patients were then randomly assigned in a 1:1 ratio to receive a standard dose ticagrelor 90 mg bid or a lower dose ticagrelor 45 mg bid in addition to aspirin 100mg. The primary efficacy end points are the event rate of the composite of cardiovascular death, non-fatal myocardial infarction, stent thrombosis, coronary revascularization and stroke at 24 months. The primary safety end point is the incidence of PLATO major bleeding at 24 months. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03620760
Study type Interventional
Source Beijing Anzhen Hospital
Contact Xiaofan Wu, MD
Phone 13370103552
Email drwuxf@163.com
Status Recruiting
Phase Phase 4
Start date August 7, 2018
Completion date December 31, 2020

See also
  Status Clinical Trial Phase
Recruiting NCT01218776 - International Survey of Acute Coronary Syndromes in Transitional Countries
Completed NCT02612116 - Comparison of Administration Strategies of Ticagrelor in Patients With Unstable Angina Pectoris, a Pharmacokinetic / Pharmacodynamic Study Phase 4
Active, not recruiting NCT02508714 - Bioresorbable Polymer ORSIRO Versus Durable Polymer RESOLUTE ONYX Stents N/A
Completed NCT02939248 - Influence of Naloxone on Ticagrelor Pharmacokinetics and Pharmacodynamics in Patients With Unstable Angina Pectoris on Concomitant Treatment With Morphine Phase 4
Active, not recruiting NCT02175706 - DUrable Polymer-based STent CHallenge of Promus ElemEnt Versus ReSolute Integrity N/A
Completed NCT01377402 - ARgentinean Risk Assessment Registry in ACS; the ARRA-RACS Study N/A
Completed NCT00521976 - Risk Markers in the Acute Coronary Syndromes
Completed NCT02144090 - Opsens Optowire for Fractional Flow Reserve - The O2 Pilot Study N/A
Completed NCT00627744 - Beta-cell Function in Glucose Abnormalities and Acute Myocardial Infarction Phase 4
Completed NCT00990262 - Rule Out Myocardial Infarction by Computer Assisted Tomography N/A
Enrolling by invitation NCT04008173 - The International Survey of Acute Coronary Syndromes-ARCHIVES
Withdrawn NCT02165670 - BASIC VALIDATE Coronary Stent Registry
Completed NCT01293097 - Intensive Statin Treatment in Chinese Coronary Artery Disease Patients Undergoing PCI Phase 4
Completed NCT01066650 - The Real-World Endeavor Resolute Versus XIENCE V Drug-Eluting Stent Study in Twente Phase 4
Completed NCT02747329 - A Comparative Evaluation of the Extent of Neointima Formation at 1 Month and 2 Months After Implantation Using OCT N/A
Completed NCT02939235 - Influence of Metoclopramide on Ticagrelor Pharmacokinetics and Pharmacodynamics in Patients With Unstable Angina Pectoris on Concomitant Treatment With Morphine Phase 4
Not yet recruiting NCT03155971 - PCB for Long De Novo Lesions of Main Coronary Arteries (D-Lesion Long Trial) N/A
Recruiting NCT04575207 - The Flash FFR Ⅱ Study N/A
Terminated NCT02235753 - High-intensity Exercise After Acute Cardiac Event (HITCARE) N/A
Completed NCT02007187 - Danhong Injection in the Treatment of Unstable Angina Pectoris Phase 4