Identification of Genetic Polymorphisms Related to Propofol Requirement and Recovery Through Genome-wide Association Study (GWAS) in Total Intravenous Anesthesia for Clipping of Unruptured Cerebral Aneurysm in Korean Population

Unruptured Cerebral Aneurysm Clinical Trial

Official title:

Identification of Genetic Polymorphisms Related to Propofol Requirement and Recovery Through Genome-wide Association Study (GWAS) in Total Intravenous Anesthesia for Clipping of Unruptured Cerebral Aneurysm in Korean Population

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03087383
• Other study ID #: 4-2017-0008
• Status: Recruiting
• Start date: March 2, 2017
• Est. completion date: March 2020

Study information

• Verified date: March 2019
• Source: Yonsei University
• Contact: Seung Ho Choi, MD
• Phone: +82 2 2228-2427
• Email: csho99[@]yuhs.ac
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

In neurosurgical anesthesia, propofol based total intravenous anesthesia (TIVA) is frequently used due to brain relaxation and less effect on electrophysiologic monitoring. Response to propofol can vary between individuals and be associated with clinical factors including age and weight, and genetic polymorphism. Because the importance of rapid recovery in neurosurgery with long operation time is emphasized recently, the choice and dose adjustment of anesthetics should be determined according to clinical and genetic factors. Recently, researches about genetic variations have been performed with single nucleotide polymorphism (SNP). The aim of this study is to find SNPs associated with propofol recovery and response through genome-wide association study (GWAS) in Korean adult population undergoing propofol based TIVA for clipping of unruptured cerebral aneurysm.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 500
• Est. completion date: March 2020
• Est. primary completion date: March 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 19 Years and older

Eligibility

Inclusion Criteria:

• Korean adult population undergoing propofol based TIVA for clipping of unruptured cerebral aneurysm

Exclusion Criteria:

• Patients not able to read, or understand the consent form

• Ethnicity, other than Korean population

• Patients refusal

• Patients not to perform total intravenous anesthesia

• Patients currently taking psychiatric medication

Related Conditions & MeSH terms

• Aneurysm
• Intracranial Aneurysm
• Unruptured Cerebral Aneurysm

Locations

Country	Name	City	State
Korea, Republic of	Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Yonsei University

Country where clinical trial is conducted

Korea, Republic of, 

References & Publications (1)

Iohom G, Ni Chonghaile M, O'Brien JK, Cunningham AJ, Fitzgerald DF, Shields DC. An investigation of potential genetic determinants of propofol requirements and recovery from anaesthesia. Eur J Anaesthesiol. 2007 Nov;24(11):912-9. Epub 2007 Jun 7. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Time of eye opening after stopping propofol infusion	When operation is finished, investigator will stop the intravenous infusion of propofol. Investigators will measure the time from when propofol infusion is stopped until eye opening and extubation, respectively. The measurement will be established within about one hour from end of surgery.	Within one hour