Respiratory Drive in Patients With Univentricular Congenital Heart Disease

Status Completed

Clinical Trial Summary

The aim is to evaluate the correlation between the respiratory control to hypercapnia at rest and the VE/VCO2 slope measured during cardiopulmonary exercise testing. The hypothesis is that patient with univentricular congenital heart disease have a increasing of respiratory drive like chronic heart failure. This increasing of respiratory drive could participate in the increasing of VE/VCO2 slope measured during cardiopulmonary exercise testing and in the genese of central apnea index during the sleep.

Clinical Trial Description

The patients with univentricular congenital heart disease will perform : - a cardiopulmonary exercise testing with measure VE/VCO2 slope, - a measure of the respiratory drive to hypercapnia with occlusion pressure during the rebreathing with at rest (P0,1/PetCO2). - A polysomnography with a scoring of central apnea index. Correlation will be evaluate between P 0,1/PetCO2 with VE/VCO2 slope and between P0,1/PetCO2 central apnea index. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03818373
Study type	Interventional
Source	University Hospital, Montpellier
Contact
Status	Completed
Phase	N/A
Start date	October 16, 2017
Completion date	July 7, 2021

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