Unilateral Cleft Lip Clinical Trial
Official title:
Evaluation of the Effect of Platelet Rich Plasma (PRP) on the Esthetic Outcome and Scar Formation of Unilateral Cleft Lip Repair by Modified Millard Cheiloplasty: A Randomized Clinical Trial
The purpose of this study is to evaluate effect of platelet rich plasma on scar formation of unilateral cleft lip repair.
PRP is a portion of the plasma fraction of autologous blood, having a platelet concentration
above baseline values. PRP is made by centrifugation of whole blood (drawn from a peripheral
vein and stored in an acid citrate dextrose solution A (ACD-A) anticoagulant), which
separates the various components of blood by their specific weight and increases the
concentration of platelets.
Platelets are a rich source of the complex group of proteins called growth factors (GFs)
involved in natural wound healing and in regeneration of injured tissues. GFs are active
signals for attracting stem cells into the site of injury and triggering proliferation of
these cells. PRP limit inflammation, interacting with macrophages to improve tissue healing
and regeneration, promote new capillary growth, and accelerate epithelialization. Platelets
in PRP also play a role in host defense mechanism at the wound site by producing signaling
proteins that attract macrophages; PRP also may contain a small number of leukocytes that
synthesize interleukins as part of a non-specific immune response. Previous studies of PRP
have demonstrated antimicrobial activity against Escherichia coli, Staphylococcus aureus,
including methicillin-resistant Staphylococcus aureus, Candida albicans, and Cryptococcus
neoforma. So, PRP is effective in soft tissue healing, having no side effect and showed
excellent healing score in skin wound healing.
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