Impact of Bi-26 Supplementation on Weight Gain in Underweight Infants

Status Active, not recruiting

Clinical Trial Summary

The burden of disease experienced by underweight children is significant, particularly in low- and middle-income countries. Gut dysbiosis, an imbalance in microbial composition, is thought to play a role in nutrient malabsorption leading to underweight infants and failure to thrive. Bifidobacterium longum subspecies infantis (B. infantis) is a commensal bacterial strain important in the breakdown of human milk oligosaccharides (HMOs). A decrease in abundance or absence of B. infantis could lead to inadequate HMO processing, elevating intestinal pH and increasing the risk of pathogen overgrowth. Bi-26 is a B. infantis probiotic strain that is being evaluated in this study for its impact on weight gain and other health outcomes in underweight infants.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05952076
Study type	Interventional
Source	Bill & Melinda Gates Medical Research Institute
Contact
Status	Active, not recruiting
Phase	Phase 3
Start date	July 3, 2023
Completion date	April 16, 2024

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