Undergoing General Anaesthesia Clinical Trial
Official title:
Risk Factors of Post Operative Cognitive Dysfunction (POCD) in General Anesthesia Patients Underwent Noncardiac and Non Neurological Procedures.
NCT number | NCT04215263 |
Other study ID # | IndonesiaUAnes 044 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | May 1, 2019 |
Est. completion date | July 5, 2019 |
Verified date | February 2020 |
Source | Indonesia University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The study was a prospective cohort study to assess the effect of age, duration of anesthesia, repeated surgery, and type of surgery on cognitive impairment in 108 geriatric patients (≥60 years) who underwent general anesthesia for non-neurologic noncardiac surgery.
Status | Completed |
Enrollment | 109 |
Est. completion date | July 5, 2019 |
Est. primary completion date | July 5, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 60 Years and older |
Eligibility |
Inclusion Criteria: - geriatric patient (age over 60) underwent noncardiac non-neurological procedure under general anesthesia - patient can do reading and writing - patient can speak in Bahasa - signing informed consent Exclusion Criteria: - patient with cognitive impairment or psychiatric disorder such as delirium, amnesia, anxiety disorder, or depression. - patient under psychotropic drugs or narcotics. - patient with history of brain tumor, head injury or motoric disturbance and disability that can disturbed neurocognitive test |
Country | Name | City | State |
---|---|---|---|
Indonesia | Indonesia University | Jakarta | DKI Jakarta |
Lead Sponsor | Collaborator |
---|---|
Indonesia University |
Indonesia,
BEDFORD PD. Adverse cerebral effects of anaesthesia on old people. Lancet. 1955 Aug 6;269(6884):259-63. — View Citation
Canet J, Raeder J, Rasmussen LS, Enlund M, Kuipers HM, Hanning CD, Jolles J, Korttila K, Siersma VD, Dodds C, Abildstrom H, Sneyd JR, Vila P, Johnson T, Muñoz Corsini L, Silverstein JH, Nielsen IK, Moller JT; ISPOCD2 investigators. Cognitive dysfunction a — View Citation
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Strøm C, Rasmussen LS, Sieber FE. Should general anaesthesia be avoided in the elderly? Anaesthesia. 2014 Jan;69 Suppl 1:35-44. doi: 10.1111/anae.12493. Review. — View Citation
van Harten AE, Scheeren TW, Absalom AR. A review of postoperative cognitive dysfunction and neuroinflammation associated with cardiac surgery and anaesthesia. Anaesthesia. 2012 Mar;67(3):280-93. doi: 10.1111/j.1365-2044.2011.07008.x. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Mini International Neuropsychiatric Interview | Score was assessed using 6 forms | 7 days |