Clinical Trials Logo
  1. Home
  2. Ultrasound
  3. NCT04657341

Sonazoid Contrast-enhanced Ultrasound in Assessing Effectiveness of Neoadjuvant Chemotherapy in Breast Cancer Patients.

Ultrasound Clinical Trial

Official title:
Sonazoid Contrast-enhanced Ultrasound in Assessing Effectiveness of Neoadjuvant Chemotherapy in Breast Cancer Patients.

Clinical Trial Summary

Sonazoid as a new generation of ultrasound contrast agent.This study based on the features of Sonazoid specific angiography and high mechanical index,the role of Sonazoid in assessing effectiveness of neoadjuvant chemotherapy in breast cancer patients was explored.

Clinical Trial Description

This is a prospective, multicenter study.More than 1000 participants will enrolled.Most of them with CEUS,MRI and pathological follow up.When enhanced MRI is needed in the neoadjuvant cycle of patients, Sonazoid-CEUS examination is added at this time point, and postoperative pathology will be used as the gold standard, so as to compare the ability of the two imaging examinations in judging the effect of neoadjuvant chemotherapy. Investigators will also record the parameter information of imaging examination, pathological type of pathological examination and immunohistochemical index, etc.Contrast-enhanced ultrasound includes lesion location, initial peak tumor volume, 1-minute tumor volume, 2-minute tumor volume, and 5-minute tumor volume, as well as the time for contrast enhancement, contrast agent clearance, and contrast agent clearance.Whether there is no enhancement area in the lesion after contrast enhancement, shape after contrast enhancement, edge after contrast enhancement, order of enhancement, uniformity of enhancement, intensity enhancement, pattern of enhancement, clear boundary after contrast enhancement, aspect ratio after contrast enhancement, etc.The magnetic field strength of the equipment is planned to be recorded in the enhanced MRI information, the name of the MRI contrast agent, the lesion location, the size of the lesion, and the scanning performance are enhanced (lump-like enhancement, non-lump-like enhancement, point-like enhancement), time-signal intensity enhancement curve, DWI signal, ADC value, etc. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04657341
Study type Observational
Source Chinese PLA General Hospital
Contact
Status Active, not recruiting
Phase
Start date August 1, 2020
Completion date December 2021
View Details
See also
  Status Clinical Trial Phase
Completed NCT04546867 - Establishing a Sonographic Based Algorithm to Verify Pancreatic Stent Position Placed to Prevent Post-ERCP Pancreatitis Before Endoscopic Removal N/A
Not yet recruiting NCT06053892 - AR US Versus sUS or Fluoroscopic Injections for Shoulder Punction N/A
Completed NCT05013476 - Tele-Ultrasound: VIrtual Hands-on Education for Novice Users N/A
Completed NCT04554472 - Usefulness of Intraoperative Ultrasound in a Volar Plate Distal Radius Fixation
Not yet recruiting NCT04550793 - Using Shear Wave Ultrasound Elastography for Follow up After Anti-spastic Intervention Among Stroke Patients
Completed NCT03563196 - Diagnosis Of Pulmonary Complications After Cardiac Surgery In Children
Completed NCT01666626 - Ultrasound Stiffness Imaging in Crohn's Disease N/A
Active, not recruiting NCT04928560 - Diagnosis of Superficial Lymphadenopathy
Recruiting NCT05938790 - Point of Care Ultrasound in Obstetric Triage N/A
Completed NCT06098105 - Laparoscopic vs Ultrasound-Guided Transversus Abdominis Plane Block vs Laparoscopic Intraperitoneal Instillation of Local Anesthetic in Pediatrics N/A
Recruiting NCT02834585 - Magnetic Resonance Imaging or Ultrasound in Soft Tissue Tumors (MUSTT) N/A
Completed NCT02661607 - Point of Care Echocardiography Versus Chest Radiography for the Assessment of Central Venous Catheter Placement N/A
Completed NCT01519167 - Open-Label, Safety Study Evaluating the Use of Dexmedetomidine in Pediatric Subjects Undergoing Procedure-Type Sedation Phase 4
Completed NCT04612816 - Live Stream of Ultrasound in Prehospital Medical Care
Active, not recruiting NCT06195488 - Gastric Ultrasound in Diabetic Patients
Recruiting NCT06199856 - Assessment System for Sarcopenia Based on Ultrasonographic Data
Not yet recruiting NCT04563897 - Prospective Multicenter Study on Clinical Application of Sonazoid in Liver Tumor
Completed NCT04574258 - Prospective Multicenter Study on Clinical Application of Sonozoid in Thyroid Tumor
Completed NCT04124770 - Neck Position and Ultrasound Landmark of Cricothyroid Membrane
Completed NCT04229654 - Awareness, Expectations, and Perception of Anomaly Scan Among Mexican Pregnant Women