Ultrasound Clinical Trial
Official title:
Does Normal Brain Imaging Predict Normal Neurodevelopmental Outcome in Fetuses With Proven Cytomegalovirus Infection?
Cytomegalovirus (CMV) is the largest member of the virus family Herpesviridae that infects
almost all humans at some point in their lives (Ross, 2004). Congenital CMV infection is
most likely to occur when the mother experiences a primary infection during pregnancy, and
it is much less common in cases of reactivation of the disease or infection by a different
CMV strain (Boppana 1999, Endres 2001). The prevalence of congenital CMV infection varies
between 0.15-2.2% (Ross 2004, Ross 2006, Malm 2007). While most infants born with congenital
CMV infection are asymptomatic, 10 to 15% show clinical findings at birth (Ross 2004).
It is generally agreed that congenital CMV infection, whether it is symptomatic or not, is a
major risk factor for perceptual deficits. However, its influence on children's future
neuropsychological functioning is less well established. Symptomatic congenital CMV
infection is a major risk factor for poor developmental outcome (Williamson 1982, Kylat
2006, Dollard 2007), but the available data regarding neuropsychological outcome for
asymptomatic children is extremely diverse (Conboy 1986, Ivarson 1997, Kashdan 1998, Temple
2000, Zhang 2007).
We evaluated the neuropsychological outcome of children with congenital cytomegalovirus
(CMV) infection and normal consecutive fetal neurosonographic examinations and determined
whether Magnetic Resonance Imaging (MRI) provided additional information in these cases.
n/a
Observational Model: Case Control, Time Perspective: Retrospective
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