Ultra-marathon Runners Clinical Trial
— UTMB_2019Official title:
Fatigability Compared Men and Women Induced According to the Distance Traveled on an Ultra-marathon in the Mountains
| Verified date | December 2022 |
| Source | Centre Hospitalier Universitaire de Saint Etienne |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
Acute physiological consequences of ultra-marathon running are still unknown, particularly in women. Some studies have suggested that the proportion of fatigue attributable to peripheral and central mechanisms varies between males and females; however, results are contradictory. The results from the investigators of the present experiment in two studies conducted in 2009 and 2012 showed that: - A large part of fatigue induced by a mountain ultra-marathon could be attributed to central fatigue in males and that, - Females exhibited less peripheral fatigue in the plantar flexors than males did after a 110-km ultra-trail-running race. According to the literature, there seems to be a plateau in fatigue after 12-15 hours of running.
| Status | Completed |
| Enrollment | 75 |
| Est. completion date | September 1, 2019 |
| Est. primary completion date | September 1, 2019 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility | Inclusion Criteria: - Subject listed in the race "2019 Mont Blanc Ultra Trail" - Affiliates or beneficiaries of social security scheme - Signed consent Exclusion Criteria: - Subject having been injured in the previous 3 months - Pregnant woman - Chronic joint diseases - Chronic or central neurological pathologies - Taking neuroactive substances that can alter corticospinal excitability - Contraindication to experimental procedures including Transcranial Magnetic Stimulation (TMS) - Taking corticosteroids in the previous 3 months |
| Country | Name | City | State |
|---|---|---|---|
| France | CHU Saint-Etienne | Saint-Étienne |
| Lead Sponsor | Collaborator |
|---|---|
| Centre Hospitalier Universitaire de Saint Etienne |
France,
Foure A, Besson T, Stauffer E, Skinner SC, Bouvier J, Feasson L, Connes P, Hautier CA, Millet GY. Sex-related differences and effects of short and long trail running races on resting muscle-tendon mechanical properties. Scand J Med Sci Sports. 2022 Oct;32 — View Citation
Pastor FS, Besson T, Varesco G, Parent A, Fanget M, Koral J, Foschia C, Rupp T, Rimaud D, Feasson L, Millet GY. Performance Determinants in Trail-Running Races of Different Distances. Int J Sports Physiol Perform. 2022 Jun 1;17(6):844-851. doi: 10.1123/ij — View Citation
Robert M, Stauffer E, Nader E, Skinner S, Boisson C, Cibiel A, Feasson L, Renoux C, Robach P, Joly P, Millet GY, Connes P. Impact of Trail Running Races on Blood Viscosity and Its Determinants: Effects of Distance. Int J Mol Sci. 2020 Nov 12;21(22):8531. — View Citation
Sabater Pastor F, Varesco G, Besson T, Koral J, Feasson L, Millet GY. Degradation of energy cost with fatigue induced by trail running: effect of distance. Eur J Appl Physiol. 2021 Jun;121(6):1665-1675. doi: 10.1007/s00421-021-04624-5. Epub 2021 Mar 5. — View Citation
Temesi J, Besson T, Parent A, Singh B, Martin V, Brownstein CG, Espeit L, Royer N, Rimaud D, Lapole T, Feasson L, Millet GY. Effect of race distance on performance fatigability in male trail and ultra-trail runners. Scand J Med Sci Sports. 2021 Sep;31(9): — View Citation
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Variation (%) of the amplitudes of the electric shock | Measured by the electrically evoked force after contraction in isometric mode of the plantar flexors | 5 or 6 day before the race and 1 hour after | |
| Secondary | Voluntary maximum forces plantar flexors | Analysis : Quantification of neuromuscular fatigue assessment; Evolution of race mechanics and the energy cost between males and females depending on the distance of the race. Measured by voluntary maximum forces plantar flexors test (seat type Cybex) in percentage (%). |
5 or 6 day before the race and 1 hour after | |
| Secondary | Voluntary maximum forces knee extensors | Analysis : Quantification of neuromuscular fatigue assessment; Evolution of race mechanics and the energy cost between males and females depending on the distance of the race. Voluntary maximum forces knee extensors measures by seat type Cybex in percentage (%). |
5 or 6 day before the race and 1 hour after | |
| Secondary | Electrically evoked forces | Analysis : Quantification of neuromuscular fatigue assessment; Evolution of race mechanics and the energy cost between males and females depending on the distance of the race. Electrically evoked forces measures by neurostimulator in percentage (%). |
5 or 6 day before the race and 1 hour after | |
| Secondary | ElectroMyoGraphic activity (EMG) | Analysis : Quantification of neuromuscular fatigue assessment; Evolution of race mechanics and the energy cost between males and females depending on the distance of the race. ElectroMyoGraphic activity (EMG) measures by electromyography. The EMG signal will be recorded with pairs of electrodes fixed with an adhesive tape bilaterally over the muscular belly. |
5 or 6 day before the race and 1 hour after | |
| Secondary | Three-Modality Evoked Potentials (TMEPs) | Analysis : Quantification of neuromuscular fatigue assessment; Evolution of race mechanics and the energy cost between males and females depending on the distance of the race. Three-Modality Evoked Potentials (TMEPs) measures by magnetic stimulator in percentage (%). |
5 or 6 day before the race and 1 hour after | |
| Secondary | Transcranial Magnetic Stimulation (TMS) | Analysis : Quantification of neuromuscular fatigue assessment; Evolution of race mechanics and the energy cost between males and females depending on the distance of the race. Measured supraspinal activation level and cortical excitation by Transcranial Magnetic Stimulation (TMS) in percentage (%). |
5 or 6 day before the race and 1 hour after | |
| Secondary | Force/Velocity Profile (FVP) | Analysis: Quantification of neuromuscular fatigue assessment; Evolution of race mechanics and the energy cost between males and females depending on the distance of the race. Measured Force/Velocity Profile (FVP) test: 2 sprints of 8 seconds on a cycle ergometer. |
5 or 6 day before the race and 1 hour after | |
| Secondary | Blood viscosity | Measured by blood sample. | 5 or 6 day before the race and 1 hour after | |
| Secondary | Number of red blood cell | Measured by blood sample. | 5 or 6 day before the race and 1 hour after | |
| Secondary | Number of platelets | Measured by blood sample. | 5 or 6 day before the race and 1 hour after | |
| Secondary | Number of white blood cells | Measured by blood sample. | 5 or 6 day before the race and 1 hour after | |
| Secondary | Rate of hemoglobin (%) | Measured by blood sample. | 5 or 6 day before the race and 1 hour after | |
| Secondary | creatinine (mg/L) | Measured by blood sample. | 5 or 6 day before the race and 1 hour after | |
| Secondary | C reactive protein (CRP) (mg/L) | Measured by blood sample. | 5 or 6 day before the race and 1 hour after | |
| Secondary | urea (g/L) | Measured by blood sample. | 5 or 6 day before the race and 1 hour after | |
| Secondary | uric acid (mg/L) | Measured by blood sample. | 5 or 6 day before the race and 1 hour after | |
| Secondary | lactate (mg/L) | Measured by blood sample. | 5 or 6 day before the race and 1 hour after | |
| Secondary | Proteinuria-density urinary (mg/24h) | Measured by urinary sample. | 5 or 6 day before the race and 1 hour after | |
| Secondary | Kinematic variable | Measured by treadmill result. | 5 or 6 day before the race and 1 hour after |
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04511858 -
Difference in Central Fatigue During Two Ultra-endurance Practices: Running vs. Cycling
|
N/A |