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Ulcer clinical trials

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NCT ID: NCT05930210 Recruiting - Diabetes Mellitus Clinical Trials

A Study to Evaluate ENERGI-F703 GEL in Diabetic Foot Ulcer

Start date: May 30, 2023
Phase: Phase 3
Study type: Interventional

This Phase 3 study is a randomized, double-blind, vehicle-controlled, multiple-center, parallel study to evaluate efficacy and safety of ENERGI-F703 GEL compared with vehicle control in subjects with Wagner Grade 1 to Grade 2 diabetic foot ulcers. Baseline target ulcer size (<16 cm2 vs ≥16 cm2 ) will be included as a stratification factor. Subjects will be randomized 1:1 to receive ENERGI-F703 GEL or vehicle control using an interactive web response system for randomization to automatically assign a unique subject randomization number. Total duration of the study will be up to 31 weeks including Screening visit (approximately 2 to 3 weeks), double-blind dosing/observation phase (16 weeks), and a safety follow-up of 12 weeks after the last administration of study treatment.

NCT ID: NCT05915169 Recruiting - Pressure Ulcer Clinical Trials

The Effects of Topical Haemoglobin Spray in Pressure Ulcer

Start date: January 1, 2024
Phase: N/A
Study type: Interventional

A prospective randomised controlled experimental study was planned to compare the effects of pressure sore dressing using topical haemoglobin and traditional gauze dressing using saline on the healing process and cost of pressure sores in patients with pressure sores.

NCT ID: NCT05895981 Recruiting - Ulcerative Colitis Clinical Trials

Exploratory Clinical Trial of Safety and Efficacy of Sacral Nerve Stimulation in Patients With Ulcerative Colitis.

Start date: July 20, 2023
Phase: N/A
Study type: Interventional

Although the incidence of inflammatory bowel disease is stable in North American and European countries, the incidence of inflammatory bowel disease is increasing in newly industrialized countries, especially in China. The treatment drugs for ulcerative colitis include 5-aminosalicylic acid (5-ASA), glucocorticoids, immunosuppressants, and biological agents. The aim of this exploratory Clinical Trial is to evaluate the safety and efficacy of sacral nerve stimulation in patients with ulcerative colitis.

NCT ID: NCT05894096 Recruiting - Venous Leg Ulcer Clinical Trials

Air Cold Atmospheric Pressure Plasma Treatment for Acceleration of Venous Ulcer Healing

PLASFRI-CUV
Start date: March 24, 2023
Phase: N/A
Study type: Interventional

In this medical trial, a novel prototype of a medical device based on a Cold Atmospheric Air Plasma Jet for the treatment is clinically tested on patients with venous leg ulcers. The device is characterized by producing the first cold air plasma jet compatible with living tissues at a low heat transfer rate with a temperature on the skin surface lower than 40 ºC. It has a practical design to be used by physicians during daily practice with a special focus on unhealed ulcers.

NCT ID: NCT05890703 Recruiting - Ulcer, Leg Clinical Trials

Painless Sharp Wound Debridement With Lidocaine-23%-Tetra-caine-7% Gel Versus EMLA 5% Cream

LIDOTETRA
Start date: June 1, 2023
Phase: Phase 2
Study type: Interventional

In a single-blind, crossover, randomized, controlled trial with 40 participants we aim to demonstrate superior anaesthetic efficacy of lidocaine-23%-tetracaine-7% (IMP2) gel over EMLA 5% cream (IMP1) at comparable safety in sharp wound debridement of chronic leg ulcers. This is a monocentric investigator initiated trial conducted in the University Hospital Zurich. In this longitudinal trial, participants receive a sequence of different treatments (treatments on different days) and therefore are randomly assigned to one of two treatment sequences. One-half of participants will first receive IMP1 (first treatment visit, randomized) and then IMP2 (second treatment visit, crossover); the other half of participants the reverse sequence (first treatment visit: IMP2, second treatment visit: IMP1). Primary Objective: We want to show that IMP 2 (lidocaine-23%-tetracaine-7% gel) is more effective in pain reduction than IMP 1 (EMLA® 5% cream) in sharp wound debridement.

NCT ID: NCT05876494 Recruiting - Ulcerative Colitis Clinical Trials

Serum Lactate and Ulcerative Colitis

Start date: June 1, 2023
Phase:
Study type: Observational

Patients presenting with severe symptoms of ulcerative colitis (UC) require hospital admission for urgent assessment and therapy. Endoscopic examination of the rectum and/or distal colon is often performed to assess severity and obtain tissue for histopathologic evaluation, but this is often extended to full colonoscopy to assess the extent of bowel involvement. Full colonoscopy is hazardous in this setting

NCT ID: NCT05867329 Recruiting - Clinical trials for Ulcerative Colitis Acute

A Trial for Acute Severe Ulcerative Colitis

Start date: September 30, 2023
Phase: Phase 4
Study type: Interventional

The goal of this trial is to create personalized treatments for each patient admitted to the hospital with acute severe ulcerative colitis (ASUC). The study will test the feasibility and acceptability of these treatment strategies among patients and physicians so that the study team can later do a larger trial to test whether the medication treatment pathways help patients avoid colectomy while ensuring patient's are safe.

NCT ID: NCT05852574 Recruiting - Ulcerative Colitis Clinical Trials

CP101 for the Treatment of Ulcerative Colitis

Start date: September 1, 2023
Phase: Phase 1
Study type: Interventional

This is a dose ranging exploratory phase 1 pilot study to assess engraftment, safety, and efficacy of CP101, an oral microbiome therapeutic, in participants with active mild-to-moderate Ulcerative colitis. A total of 30 patients who meet eligibility criteria will be randomized 1:1 to either a short or extended induction dosing with CP101. An assessment of the microbiome will occur at baseline, Day 6, Week 4, Week 8, Week 12, Week 16, and Week 24.

NCT ID: NCT05850611 Recruiting - Clinical trials for Diabetic Foot Ulcers

The Effect of Combination Therapy of Oral MB and PRP-FG in Patients With Non-healing Diabetic Foot Ulcer

Start date: April 30, 2023
Phase: Early Phase 1
Study type: Interventional

The aim of this study is to evaluate the chance of non-healing diabetic foot ulcers repair by improving the condition of lack of oxygen or hypoxia in the wound area caused by diabetes using methylene blue along with the use of platelet-rich plasma-fibrin glue as an effective treatment for wound healing.

NCT ID: NCT05831670 Recruiting - Colitis, Ulcerative Clinical Trials

An Early Phase 2 Clinical Study of KSP-0243

Start date: April 27, 2023
Phase: Phase 2
Study type: Interventional

A phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study to administer KSP-0243 or a placebo once daily after breakfast for 8 weeks in 100 patients with mild to moderate active ulcerative colitis.