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Ulcer clinical trials

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NCT ID: NCT05242484 Recruiting - Colitis, Ulcerative Clinical Trials

A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis

DUET-UC
Start date: September 19, 2022
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of JNJ-78934804 as compared to guselkumab and golimumab in participants with moderately to severely active ulcerative colitis who have had an inadequate initial response, loss of response, or intolerance to one or more approved advanced therapy.

NCT ID: NCT05241704 Recruiting - Varicose Ulcer Clinical Trials

Endovenous Ablation Combined With Fat Grafting for Venous Ulcers

Start date: February 2022
Phase: N/A
Study type: Interventional

The aim of this trial is to determine if fat grafting may have applicability to venous ulcers by comparing healing and recurrence rates in patients who receive combined fat grafting and endovenous ablation with patients who receive endovenous ablation only

NCT ID: NCT05239702 Recruiting - Ulcerative Colitis Clinical Trials

Clinical Study of Targeting CD7 CAR-T Cells in the Treatment of Autoimmune Diseases

Start date: February 28, 2022
Phase: Early Phase 1
Study type: Interventional

A Clinical Study on the Safety and Effectiveness of Targeting CD7 Chimeric Antigen Receptor T Cells in the Treatment of Autoimmune Diseases

NCT ID: NCT05239416 Recruiting - Varicose Ulcer Clinical Trials

Fat Grafting in Reducing Recurrence in Patients With Healed Venous Ulcers A Prospective Randomised Clinical Pilot Study

Start date: February 2022
Phase: N/A
Study type: Interventional

In this study, investigators aim to use fat grafting in patients with previously healed venous ulcers to study its role on increasing skin thickness and reconstructing skin layers which was damaged by venous hypertension and determine its impact on reducing recurrence rates at 1 year

NCT ID: NCT05236660 Recruiting - Diabetic Foot Ulcer Clinical Trials

Personalised Assistive Devices Approach for Diabetic Foot Ulcer Prevention

DIASSIST
Start date: March 2, 2022
Phase: N/A
Study type: Interventional

Preventing foot ulcers in people with diabetes can reduce costs and increase quality of life. Despite availability of various interventions to prevent foot ulcers, recurrence rates remain high. We hypothesise that a multimodal approach incorporating a variety of orthotic interventions that matches an individual person's need can reduce ulcer recurrence with beneficial cost-effectiveness and cost-utility.

NCT ID: NCT05234086 Recruiting - Wound Heal Clinical Trials

Cell Therapy for Diabetic Foot Ulcer

Start date: January 2, 2020
Phase: Phase 2
Study type: Interventional

Diabetes is a highly prevalent chronic disease that affects a large part of the world's population. Among the most costly complications is the diabetic foot ulcer, where its decompensation can result in limb amputation, a risk 10 to 20 times more frequent for diabetic population. Two underlying pathophysiological mechanisms are mainly identified: neuropathy and problems associated with vasculature and blood supply, in addition to the incidence of infections, which further impairs prognosis. Skin regeneration involves several overlapping and consecutive stages, which in the case of a diabetic patient are altered. Although healing protocols have been significantly improved at the country level, and there is also a large amount of medical supplies for treatment of these wounds, there are still patients with ulcers refractory to this care that end in amputation. In response to this, new treatments have emerged that use biomaterials and cells of the patient himself, which attempt to emulate the architecture and functionality of normal tissue. Cell therapy has gained strength in recent years, with more and more studies indicating the positive effect of cell application on healing of chronic wounds with underlying pathologies, such as diabetes. The product to be evaluated corresponds to a combined medical device, which conveys a cellular therapy, known as InbioDerm+C. The purpose of this Phase II clinical study is to determine whether InbioDerm+C treatment plus advanced healing is equal to or superior to advanced healing in a diabetic population with Wagner II grade foot ulcer treated in Villa Alemana primary care family centers, Las Américas, Juan Bautista Bravo Vega and Eduardo Frei.

NCT ID: NCT05230875 Recruiting - Ulcerative Colitis Clinical Trials

Sexual Dysfunction Among Inflammatory Bowel Disease Adults-Clinical Trial

SexIA-CT
Start date: April 7, 2022
Phase:
Study type: Observational

Patients with Inflammatory Bowel Disease (IBD) have higher rates of sexual dysfunction than the general population. We offer an educational program on IBD including a specific discussion on intimacy and sexuality for IBD patients. Our objective is to investigate the benefit of this intervention on sexual function in patients with IBD.

NCT ID: NCT05228340 Recruiting - Clinical trials for Foot Ulcer, Diabetic

Flexor Tenotomy and Ulcer Recurrence

Start date: March 15, 2022
Phase: N/A
Study type: Interventional

The main purpose of this study is to assess the efficacy of flexor tenotomy on the prevention of recurrence of toe ulcers in people with diabetes and a history of toe ulceration. Additionally, the investigators aim to assess interphalangeal joints (IPJ) and metatarsophalangeal joint (MTPJ) angles in a weight-bearing and non-weight-bearing position, bare-foot plantar pressure during walking and quality of life before and after the intervention and compare between study groups.

NCT ID: NCT05225545 Recruiting - Ulcerative Colitis Clinical Trials

Sucrosomial Iron vs. Oral Iron Sulfate for the Treatment of Iron Deficiency Anemia in Patients With Ulcerative Colitis

Start date: November 4, 2019
Phase: Phase 3
Study type: Interventional

The aim of the study is to compare the tolerability and efficacy of Sucrosomial Iron to Oral Iron Therapy in a randomized controlled trial for the treatment of Iron Deficiency Anemia in Ulcerative Colitis patients.

NCT ID: NCT05218850 Recruiting - Ulcerative Colitis Clinical Trials

The Use of Butyrate Therapy in Pediatric Ulcerative Colitis

Start date: June 29, 2022
Phase: Phase 1
Study type: Interventional

Butyrate is an important metabolite produced by the gut microbiome and has been shown as a helpful therapy in ulcerative colitis. This is a feasibility study to determine the efficacy of butryate enemas in pediatric ulcerative colitis.